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Title

Effect of new antioxidant cysteinyl-flavanol conjugates on skin cancer cells

AuthorsLozano, Carles; Torres, Josep Lluís CSIC ORCID; Juliá, Lluís CSIC ORCID; Jiménez, Aurora; Centelles, Josep J.; Cascante, Marta CSIC ORCID
KeywordsCatechins
Antioxidants
Gallate ester
Melanoma
Cell cycle
Apoptosis
Issue Date14-Jul-2005
PublisherElsevier
CitationFEBS Letters 579(20): 4219-4225 (2005)
AbstractNovel catechin derivatives obtained from grape procyanidins and l-cysteine scavenge free radicals by hydrogen atom donation, rather than electron transfer, and reduce cell viability in A375 and M21 melanoma cells. In particular, 4β-(S-cysteinyl)epicatechin 3-O-gallate has a free radical scavenging capacity as strong as that of tea (−)-epigallocatechin gallate and causes a significant S-phase cell-cycle arrest in both cell lines at doses higher than 100 μM. The other cysteinyl compounds do not affect normal cell cycle distribution. The gallate derivative also induces apoptosis in melanoma cells more strongly than the other derivatives and the parent (−)-epicatechin do. The gallate compound seems to trigger nuclear condensation and fragmentation, which is confirmed by DNA laddering. Interestingly, they do not induce apoptosis in keratinocytes (HaCaT).
Description7 pages, 6 figures, 2 tables.-- PMID: 16051220 [PubMed].-- Printed version published Aug 15, 2005.-- Edited by Vladimir Skulachev.
Publisher version (URL)http://dx.doi.org/10.1016/j.febslet.2005.06.051
URIhttp://hdl.handle.net/10261/15642
DOI10.1016/j.febslet.2005.06.051
ISSN0014-5793
E-ISSN1873-3468
Appears in Collections:(IQAC) Artículos

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