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Título

Effect of new antioxidant cysteinyl-flavanol conjugates on skin cancer cells

AutorLozano, Carles; Torres, Josep Lluís; Juliá, Lluís; Jiménez, Aurora; Centelles, Josep J.; Cascante, Marta
Palabras claveCatechins
Antioxidants
Gallate ester
Melanoma
Cell cycle
Apoptosis
Fecha de publicación14-jul-2005
EditorElsevier
CitaciónFEBS Letters 579(20): 4219-4225 (2005)
ResumenNovel catechin derivatives obtained from grape procyanidins and l-cysteine scavenge free radicals by hydrogen atom donation, rather than electron transfer, and reduce cell viability in A375 and M21 melanoma cells. In particular, 4β-(S-cysteinyl)epicatechin 3-O-gallate has a free radical scavenging capacity as strong as that of tea (−)-epigallocatechin gallate and causes a significant S-phase cell-cycle arrest in both cell lines at doses higher than 100 μM. The other cysteinyl compounds do not affect normal cell cycle distribution. The gallate derivative also induces apoptosis in melanoma cells more strongly than the other derivatives and the parent (−)-epicatechin do. The gallate compound seems to trigger nuclear condensation and fragmentation, which is confirmed by DNA laddering. Interestingly, they do not induce apoptosis in keratinocytes (HaCaT).
Descripción7 pages, 6 figures, 2 tables.-- PMID: 16051220 [PubMed].-- Printed version published Aug 15, 2005.-- Edited by Vladimir Skulachev.
Versión del editorhttp://dx.doi.org/10.1016/j.febslet.2005.06.051
URIhttp://hdl.handle.net/10261/15642
DOI10.1016/j.febslet.2005.06.051
ISSN0014-5793 (Print)
1873-3468 (Online)
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