Multicomponent reactions in the synthesis of target molecules

Abstract

Multicomponent reactions are a powerful tool in the synthesis of complex target molecules because multiple bonds are effectively built up in one step from relatively simple building blocks. They introduce molecular diversity in only one step and do so in a highly efficient and convergent manner. Heterocycles are structural motifs that are often found in bioactive molecules or drugs, therefore the high yielding and fewer steps synthesis of these compounds is of great interest for Medicinal Chemistry. Here, we will discuss some multicomponent strategies to synthesize heterocycles like indoles, pyrroles, spiro-type polyheterocycles, fused polyheterocycles, dihydropyrimidines, thiazines, as well as amino acids.