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Title

Study of Galfenol direct cytotoxicity and remote microactuation in cells

AuthorsVargas-Estevez, Carolina; Blanquer, Andreu; Dulal, Prabesh; Pérez del Real, Rafael ; Duch, Marta; Ibáñez, Elena ; Barrios, Leonardo; Murillo, Gonzalo; Torras, Núria; Nogués, Carme; Stadler, Bethanie J. H.; Plaza, José Antonio ; Esteve i Tintó, Jaume
KeywordsGalfenol
Magnetostriction
Smart materials
Microactuators
Biocompatibility
Osteoblast
Issue DateSep-2017
PublisherElsevier
CitationBiomaterials 139: 67-74 (2017)
AbstractRemote microactuators are of great interest in biology and medicine as minimally-invasive tools for cellular stimulation. Remote actuation can be achieved by active magnetostrictive transducers which are capable of changing shape in response to external magnetic fields thereby creating controlled displacements. Among the magnetostrictive materials, Galfenol, the multifaceted iron-based smart material, offers high magnetostriction with robust mechanical properties. In order to explore these capabilities for biomedical applications, it is necessary to study the feasibility of material miniaturization in standard fabrication processes as well as evaluate the biocompatibility. Here we develop a technology to fabricate, release, and suspend Galfenol-based microparticles, without affecting the integrity of the material. The morphology, composition and magnetic properties of the material itself are characterized. The direct cytotoxicity of Galfenol is evaluated in vitro using human macrophages, osteoblast and osteosarcoma cells. In addition, cytotoxicity and actuation of Galfenol microparticles in suspension are evaluated using human macrophages. The biological parameters analyzed indicate that Galfenol is not cytotoxic, even after internalization of some of the particles by macrophages. The microparticles were remotely actuated forming intra- and extracellular chains that did not impact the integrity of the cells. The results propose Galfenol as a suitable material to develop remote microactuators for cell biology studies and intracellular applications.
Publisher version (URL)https://doi.org/10.1016/j.biomaterials.2017.05.049
URIhttp://hdl.handle.net/10261/156290
DOI10.1016/j.biomaterials.2017.05.049
ISSN0142-9612
E-ISSN1878-5905
Appears in Collections:(IMB-CNM) Artículos
(ICMM) Artículos
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