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Título

Identification from a positional scanning peptoid library of in vivo active compounds that neutralize bacterial endotoxins

AutorMora, Puig; Masip, Isabel; Cortés, Nuria; Marquina, Regina; Merino, Ramón ; Merino, Jesús; Carbonell, Teresa; Mingarro, Ismael; Messeguer Peypoch, Ángel; Pérez-Payá, Enrique
Palabras clavePositional scanning peptoid library
Vivo active compounds
Lipopolysaccharide (LPS)
Peptoids
Fecha de publicación2-feb-2005
EditorAmerican Chemical Society
CitaciónJournal of Medicinal Chemistry 48(4): 1265–1268 (2005)
ResumenTwo peptoids that neutralize the Gram-negative lipopolysaccharide (LPS) were identified from the screening of a positional scanning library. The evaluation of the in vivo activity of these compounds in an endoxemia murine model is also reported. These peptoids did not neutralize lipid A, i.e., the hydrophobic toxic component of LPS. This fact suggests that they do not have access to the micellar core and that they should bind to the hydrophilic carbohydrate portion of LPS.
Descripción4 pages, 3 figures, 1 table.-- PMID: 15715495 [PubMed].-- Printed version published Feb 24, 2005.-- Supporting information available at: http://pubs.acs.org/doi/suppl/10.1021/jm040834i
Versión del editorhttp://dx.doi.org/10.1021/jm040834i
URIhttp://hdl.handle.net/10261/15619
DOI10.1021/jm040834i
ISSN0022-2623 (Print)
1520-4804 (Online)
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