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Identification from a positional scanning peptoid library of in vivo active compounds that neutralize bacterial endotoxins

AuthorsMora, Puig; Masip, Isabel ; Cortés, Nuria ; Marquina, Regina; Merino, Ramón ; Merino, Jesús; Carbonell, Teresa; Mingarro, Ismael; Messeguer Peypoch, Ángel ; Pérez-Payá, Enrique
KeywordsPositional scanning peptoid library
Vivo active compounds
Lipopolysaccharide (LPS)
Issue Date2-Feb-2005
PublisherAmerican Chemical Society
CitationJournal of Medicinal Chemistry 48(4): 1265–1268 (2005)
AbstractTwo peptoids that neutralize the Gram-negative lipopolysaccharide (LPS) were identified from the screening of a positional scanning library. The evaluation of the in vivo activity of these compounds in an endoxemia murine model is also reported. These peptoids did not neutralize lipid A, i.e., the hydrophobic toxic component of LPS. This fact suggests that they do not have access to the micellar core and that they should bind to the hydrophilic carbohydrate portion of LPS.
Description4 pages, 3 figures, 1 table.-- PMID: 15715495 [PubMed].-- Printed version published Feb 24, 2005.-- Supporting information available at: http://pubs.acs.org/doi/suppl/10.1021/jm040834i
Publisher version (URL)http://dx.doi.org/10.1021/jm040834i
Appears in Collections:(IQAC) Artículos
(CIB) Artículos
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