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Selective C-H bond functionalization of 2-(2-thienyl)-pyridine by a rhodium n-heterocyclic carbene catalyst

AutorRubio-Pérez, Laura ; Iglesias, Manuel ; Oro, Luis A.
Fecha de publicación2015
CitaciónOMCOS18 (2015)
ResumenThiophene moieties are present in a great number of natural and synthetic organic molecules, which include pharmacologically active heterocyclic compounds and thiophene-based materials. The development of new transition-metal catalyzed C-C bond formation via C-H activation has been revealed as a very powerful, selective an atom-economical transformation that has pushed forward organic synthesis in the last decade. We have developed a Rh-catalyzed functionalization of 2-(thiophen-2- yl)pyridine with unactivated internal alkynes and terminal olefins by directed C-H activation. This reaction renders moderate to excellent yields and high selectivities for the hydroarylation of a wide range of internal alkynes and terminal alkenes under relatively mild conditions. (Scheme 1: Hydroarylation of 2-(thiophen-2-yl)pyridine with alkenes and alkynes by Rh-NHC catalyst).
DescripciónResumen del póster presentado al Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS) IUPAC International Symposium, celebrado en Sitges-Barcelona (España) del 28 de junio al 2 de julio de 2015.
URIhttp://hdl.handle.net/10261/156001
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