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Applications of water soluble phospanes and their gold complexes: new ceramic pigments and molecular therapy
|Abstract:||The ability of the phosphane 1,3,5-triaza-7-phosphadaamante (PTA) to trasmit its water solubility to their gold complexes has permited the synthesis of complexes that found applications in a wide of different areas. In this commmunication we present results of our group as new ceramic pigments or as molecular therapy againts cancer and alzheimer. The use of ploter for the new type of ceramics requires the shynthesis of new inks able to develop the colors in the oven at high temperature. The gold complexes are selected for the formation of magenta red color. The new ink should be soluble in water of at least in alcholic media for enviromental aspects. Regarding their use as new agents of molecular therapy, we present results against different types of cancer cells, both in vitro and in vivo. Among the new non platinum complexes as potential anticancer drug, gold(I) derivatives have gained increasing attention due to the observation that the action mechanism is different to the cis-platinum and non interaction with DNA occurs, and inhibit the enzyme thioredoxin reductasa, (TrxR), making these complexes very appropriate for a second treatment against cis-platinum resistance cancer. The side effects of most of the new anticancerous complexes could be given due to their lipophilicity. For this reason, in the design of new metallic drugs, a balance between hydrophilicity and lipophilicity is required to be water soluble and at the same time be able to pass through the phospholipid cell membrane. Accordingly, water solubility of the drugs could provide such balanced relationship. The ability of PTA to reduce Cu(II) and stabilize Cu(I) as a thetraedral coordinated compound has been reported by Pombeiro et al. Bearing this in mind, several experiments have been carried out to show the ability of PTA to reduce Cu(II) to Cu(I) in physiological conditions and its ability to remove copper ions from Aβ amyloide stoping in ROS production, which is one important aspect in Alzheimer disease.|
|Description:||Resumen del trabajo presentado al Workshop “Metal, water and Sun", celebrado en Almeria (España) del 21 al 22 de mayo de 2015.|
|Appears in Collections:||(ISQCH) Comunicaciones congresos|
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