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Broad band Microcoils for inline/insitu reaction monitoring

AutorGómez, M. Victoria; Juan, Alberto; Hoz, Antonio de la; Urriolabeitia, Esteban P.
Fecha de publicación2015
CitaciónXII Simposio de Investigadores Jóvenes RSEQ Sigma-Aldrich (2015)
ResumenNuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique employed in many areas of research. NMR spectroscopy provides both, qualitative and quantitative information from a reaction, and is a non‐invasive analytical method, among other advantages. When dealing with small amount of material, there is a limitation in sensitivity in comparison with other tecniques. The use of miniature NMR detectors, termed “microcoils”, is an interesting approach to overcome this “weakness”. Different microcoil geometries, planar, solenoidal, microslot and stripline can be used, allowing the analysis of mass-limited and volume-limited samples with an improvement of sensitivity compared to the conventional NMR probe. Planar microcoils are easier to integrate in microfabrication processes allowing a precisely controlled geometry and an accurate coil sample positioning. Hence, planar microcoils can be integrated on top of a glass substrate defining a microfluidic NMR device called “NMR-­chip”. We are focused on the use of NMR-­chips for different applications. On one hand, we keep optimizing the concept of NMR‐chip in terms of looking for the highest sensitivity and resolution to open a wider window of applications, and on the other hand, the different NMR-­chip generations are hyphenated to alternate modes of heating/irradiating a reaction mixture for in-­situ/ in-­line reaction monitoring. These NMR‐chips offer, among others, two fascinating aspects: In terms of NMR, the broad‐band character for these planar microcoils has allowed us the acquisiton of all kind of homo‐ and heteronuclear 1D & 2D NMR experiments and with a single non‐tuned microcoil. In relation with their properties as monitoring tools, the capability of the NMR chip of analysing very small volume of sample enables the adquisition of data in a rapid manner, allowing a fast determination of kinetic parameters within a single on‐flow experiment and only using microliters of sample. We will illustrate the latest developments in optimization of the NMR probe, i.e. with the incorporation of pulsed field gradients and its combination with broad‐ band character, and the hyphenation of these NMR detectors to other energy sources for activation of chemical reactions, i.e. a continuous-­flow microreactor platform or UV-VIS devices for in-line and/or in‐situ monitoring of different types of chemical reactions.
DescripciónResumen del trabajo presentado al XII Simposio de Investigadores Jóvenes de la Real Sociedad Española de Química Sigma-Aldrich, celebrado en Barcelona del 3 al 6 de noviembre de 2015.-- et al.
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