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Health and safety in the consumption of B. rapa: A nutraceutical vegetable

AuthorsMerinas-Amo, T.; Alonso Moraga, Ángeles; Mateo-Fernández, M.; Fernández-Bedmar, Zahira; Haro Bailón, Antonio de ; Lozano, María Dolores
Issue DateSep-2016
Citation52nd Congress of the European Societies of Toxicology (2016)
AbstractCurrent diet is composed by a variety of food adapted to mod- ern living habits. However, recent studies classify some of these meals as undesirable for human health and have produced a grow- ing concern about what we eat and its safety. This is the case of Brassica rapa , a vegetable consumed since antiquity for its whole- some properties but now branded as not recommended due to the toxic effects of some of their constituents. Surprisingly, glucosi- nolate molecules seem to be the responsibles of both effects. In order to elucidate the toxicity of this species, we have selected the in vivo Drosophila melanogaster system as a well proved method to reproduce the human food ingests and the effect of nourish- ment in the genome. With this purpose, three B. rapa accessions selected for their different glucosinolate content were assessed in the Somatic Mutation and Recombination Test (S.M.A.R.T.), as well as gluconapin, the most abundant B. rapa glucosinolate. Our results showeddifferencein B.rapa toxicityrelatedtoitsglucosinolatepro- file and a dose effect-in Drosophila survival after gluconapin oral administration. Also, B. rapa accession with less gluconapin con- tent resulted genotoxic in the S.M.A.R.T. test, contrarily the other accessions which were evaluated as antigenotoxic together with gluconapin. In conclusion, the toxic properties of B. rapa as edible vegetable have been related to the glucosinolate content present in the plant. In this sense, B. rapa accessions with higher gluconapin content exert DNA protection properties and could be recommended for human consumption as safe and healthy.
DescriptionTrabajo presentado en el 52nd Congress of the European Societies of Toxicology (EUROTOX 2016), celebrado en Sevilla del 4 al 7 de septiembre de 2016.
Appears in Collections:(IAS) Comunicaciones congresos
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