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Modulator role of trilinolein/triolein and resveratrol on the health promoting effects of processed foods: Edible oils and red wine

AuthorsFernández-Bedmar, Zahira; Arenas-Chaparro, R.; Merinas-Amo, T.; Mateo-Fernández, M.; Tasset-Cuevas, Inmaculada; Lozano, María Dolores ; Haro Bailón, Antonio de ; Campos-Sánchez, Juan
Issue DateSep-2016
Citation52nd Congress of the European Societies of Toxicology (2016)
AbstractDiet is considered the most important source of health-promoter components. These constituents could induce a better life quality and prevent different aging and mutation mechanisms involved in the appearance of chronic diseases like cancer. The aim of this work was to evaluate the health promoting prop- erties of walnut and olive oils, red wine and their distinctive molecules (trilinolein, triolein and resveratrol respectively) assess- ing on their geno/antigenotoxic, longevity and cytotoxic roles. In order to determine the food safety and the protective DNA effect the in vivo Somatic mutation and recombination test (SMART test) of Drosophila melanogaster was used. Drosophila was also chosen as a genetic model organism to study the influence on longevity of the different substances. Finally, the chemopreventive effect was in vitro evaluatedbythetrypanblueexclusiontestusingthehuman promyelocytic leukemia cell line (HL60). Results showed that: (i) none of the tested substances is genotoxic except trilinolein at the highest assayed concentration (0.056mM), (ii) all substances exert antimutagenic activity (except walnut oil) reaching different inhi- bition percentages when hydrogen peroxide is used as genotoxin, (iii) red wine is the best inductor of longevity at moderate concen- trations, (iv) the only substances with chemopreventive cytotoxic effects are red wine and resveratrol (IC50=18 m L/mL and 110mM respectively).In conclusion, among the three tested foods, red wine could be considered the best health promoter at moderate concen- trations due to its anti/genotoxic, cytotoxic and longevity effects.
DescriptionTrabajo presentado en el 52nd Congress of the European Societies of Toxicology (EUROTOX 2016), celebrado en Sevilla del 4 al 7 de septiembre de 2016.
Appears in Collections:(IAS) Comunicaciones congresos
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