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Título

Androgen metabolism in invertebrates and its modulation by xenoandrogens: a comparative study

AutorJaner, Gemma; LeBlanc, G. A.; Porte Visa, Cinta
Palabras claveAndrogen
Steroid metabolism
Organotin
Fenarimol
Invertebrates
Fecha de publicaciónabr-2005
EditorNew York Academy of Sciences
Blackwell Publishing
CitaciónAnnals of the New York Academy of Sciences 1040: 354-356 (2005)
ResumenMarisa cornuarietis (Mollusc), Hyalella azteca (Crustacean), and Paracentrotus lividus (Echinoderm) demonstrated the ability to metabolize androgens through different pathways catalyzed by 5α-reductases (5α-R), hydroxysteroid dehydrogenases (HSD), hydroxylases, sulfotransferases (SULT), and fatty-acid acyl-CoA acyltransferases (ATAT). Interspecies differences and tissue-specific distribution of those enzymatic activities were observed. Xenobiotics, such as triphenyltin, tributyltin, and fenarimol, interfered with some of the pathways studied, namely, testosterone sulfation, testosterone esterification, and 5α-R activity. The work evidenced different sensitivity of those pathways to androgenic compounds, together with interphyla differences in androgen metabolism.
Descripción3 pages, 1 table.-- PMID: 15891060 [PubMed].-- Available online Jan 12, 2006.-- Issue title: "Trends in Comparative Endocrinology and Neurobiology".
Versión del editorhttp://dx.doi.org/10.1196/annals.1327.060
URIhttp://hdl.handle.net/10261/15580
DOI10.1196/annals.1327.060
ISSN0077-8923 (Print)
1749-6632 (Online)
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