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FGF signalling promotes proliferation of tracheal adult progenitors in Drosophila

AuthorsMiguel-Vijandi, C. de; Cruz, Josefa ; Martín Casacuberta, David A. ; Casacuberta, Elena ; Franch-Marro, Xavier
Issue DateNov-2016
CitationXXVIII Developmental Biology Meeting (2016)
AbstractThe fibroblast growth facto r (FGF) pathway plays a major role in several biological processes, like cell migration, axis specification and mesoderm formation. In vertebrates, FGF signalling also has a role in the control of cell proliferation and its deregulation is observed in many cancer types. In contrast, in Drosophila, FGf signalling plays a role in cell migration of mesoderm and tracheal cells without any direct mitogenic effect. The Drosophila tracheal system is remodeled during metamorphosis by populations of adult progenitor cells that divide under control of the transcription factor cut . These cells, late in development, migrate upon activation of FGF signalling to form the adult trachea network. Here, we show that, contrary to previous reports, the tracheal adult progenitor proliferation depends on the activation of FGF signalling. Thus, overexpression of the FGF ligand branchless induces adult progenitor over -­‐ p roliferation whereas inactivation of the pathway blocks cell division. Moreover, we show that the FGF mitogenic effect is mediated by the transcription factor Pointed. Finally, we demonstrate that the expression of cut in adult progenitors is only required to modulate FGF action by maintaining the proliferative fate of these cells. Altogether, our results show a dual role of FGF signalling during tracheal remodelling, first inducing the proliferation of cut -­‐ expressing adult progenitor cells and then inducin g the migration of these cells once cut expression is switched off.
DescriptionTrabajo presentado en la XXVIII Developmental Biology Meeting, celebrado en Barcelona el 18 de noviembre de 2016.
Appears in Collections:(IBE) Comunicaciones congresos
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