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Squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27: synthesis and mechanism of action

AutorQuintana, Mireia; Alegre-Requena, Juan V. ; Marqués-López, Eugenia ; Herrera, Raquel P.; Triola Guillem, Gemma
Fecha de publicación2016
EditorRoyal Society of Chemistry (Great Britain)
CitaciónMedChemComm 7: 550-561 (2016)
ResumenA series of squaramates and squaramides have been synthesized and their cytotoxic activity has been investigated in different cancer cell lines. Among the studied compounds, squaramide 34 showed a potent and selective cytotoxicity against the human gastric cancer cell line HGC-27. Studies directed to elucidate the mechanism of induced cell death were performed. Cell cycle distribution analysis and cell death studies showed that compound 34 induces cell cycle arrest at the G phase and caspase-dependent apoptosis. In conclusion, squaramide 34 can be considered a potential anticancer agent for gastric carcinoma.
Versión del editorhttps://doi.org/10.1039/C5MD00515A
URIhttp://hdl.handle.net/10261/155717
DOI10.1039/C5MD00515A
Identificadoresdoi: 10.1039/C5MD00515A
e-issn: 2040-2511
issn: 2040-2503
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