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Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease

AutorRzepnikowska, Weronika; Flis, Krzysztof; Muñoz-Braceras, Sandra ; Escalante, Ricardo ; Zoladek, Teresa
Palabras claveBudding yeast
Chorea-acanthocytosis (ChAc)
Chorein
Cohen syndrome
Dictyostelium discoideum
Saccharomyces cerevisiae
Fecha de publicación2017
EditorJohn Wiley & Sons
CitaciónTraffic 18(11): 711-719 (2017)
ResumenHuman Vps13 proteins are associated with several diseases, including the neurodegenerative disorder Chorea-acanthocytosis (ChAc), yet the biology of these proteins is still poorly understood. Studies in Saccharomyces cerevisiae, Dictyostelium discoideum, Tetrahymena thermophila and Drosophila melanogaster point to the involvement of Vps13 in cytoskeleton organization, vesicular trafficking, autophagy, phagocytosis, endocytosis, proteostasis, sporulation and mitochondrial functioning. Recent findings show that yeast Vps13 binds to phosphatidylinositol lipids via 4 different regions and functions at membrane contact sites, enlarging the list of Vps13 functions. This review describes the great potential of simple eukaryotes to decipher disease mechanisms in higher organisms and highlights novel insights into the pathological role of Vps13 towards ChAc.
Versión del editorhttps://doi.org/10.1111/tra.12523
URIhttp://hdl.handle.net/10261/155558
DOI10.1111/tra.12523
ISSN1398-9219
E-ISSN1600-0854
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