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dc.contributor.authorTorres-Lagares, Daniel-
dc.contributor.authorCastellanos-Cosano, Lizett-
dc.contributor.authorSerrera-Figallo, María Ángeles-
dc.contributor.authorGarcía-García, Francisco J.-
dc.contributor.authorLópez-Santos, Carmen-
dc.contributor.authorBarranco, Ángel-
dc.contributor.authorRodríguez Gonzalez-Elipe, Agustín-
dc.contributor.authorRivera-Jiménez, Cristóbal-
dc.contributor.authorGutiérrez-Pérez, José-Luis-
dc.identifierdoi: 10.3390/polym9090410-
dc.identifier.citationPolymers 9 (9): 410 (2017)-
dc.description.abstractThe novelty of this study is the addition of an ultrathin layer of nanostructured hydroxyapatite (HA) on oxygen plasma modified poly(lactic–<i>co</i>–glycolic) (PLGA) membranes (PO<sub>2</sub>) in order to evaluate the efficiency of this novel material in bone regeneration. Methods: Two groups of regenerative membranes were prepared: PLGA (control) and PLGA/PO<sub>2</sub>/HA (experimental). These membranes were subjected to cell cultures and then used to cover bone defects prepared on the skulls of eight experimental rabbits. Results: Cell morphology and adhesion of the osteoblasts to the membranes showed that the osteoblasts bound to PLGA were smaller and with a lower number of adhered cells than the osteoblasts bound to the PLGA/PO<sub>2</sub>/HA membrane (<i>p</i> < 0.05). The PLGA/PO<sub>2</sub>/HA membrane had a higher percentage of viable cells bound than the control membrane (<i>p</i> < 0.05). Both micro-CT and histological evaluation confirmed that PLGA/PO<sub>2</sub>/HA membranes enhance bone regeneration. A statistically significant difference in the percentage of osteoid area in relation to the total area between both groups was found. Conclusions: The incorporation of nanometric layers of nanostructured HA into PLGA membranes modified with PO<sub>2</sub> might be considered for the regeneration of bone defects. PLGA/PO<sub>2</sub>/HA membranes promote higher osteosynthetic activity, new bone formation, and mineralisation than the PLGA control group.-
dc.description.sponsorshipThis study has been subsidised by the Consejería de Salud of the Junta de Andalucia through project PI-0047-2013: “Innovation in Nanomedicine: Guided Bone Regeneration with Nanofunctionalised Resorbable Membranes (Nanorog)”. The authors also thank the AEI (EU FEDER program Project MAT2016-79866-R)-
dc.description.sponsorshipWe acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.relation.isversionofPublisher's version-
dc.titleIn Vitro and in Vivo Study of Poly(Lactic–co–Glycolic) (PLGA) Membranes Treated with Oxygen Plasma and Coated with Nanostructured Hydroxyapatite Ultrathin Films for Guided Bone Regeneration Processes-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderJunta de Andalucía-
dc.contributor.funderEuropean Commission-
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