English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/155422
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

NG2-glia from pallial progenitors produce the largest clonal clusters of the brain: Time frame of clonal generation in cortex and olfactory bulb

AutorGarcía-Marqués, Jorge ; Núñez-Llaves, R.; Lopez-Mascaraque, Laura
Palabras claveClonal analysisin Utero electroporation NG2 Olfactory bulb Polydendrocytes Star Track
Fecha de publicación2014
EditorSociety for Neuroscience
CitaciónJournal of Neuroscience 34: 2305- 2313 (2014)
ResumenNG2-glia are the most unknown population originating in the CNS. Despite their relative abundance in the brain, fundamental questions about their function, heterogeneity, and origin remain in debate. Particularly, it is still intriguing how these cells escaped from classical in vivo clonal analyses describing other neural types. Using StarTrack labeling in mouse brains, we found that NG2-glia are produced as immense clonal clusters whose number of cells is about one order of magnitude higher than in other neural types. Unexpectedly, this number remained low during embryonic and early postnatal stages, increasing during adulthood. In addition, we also demonstrated a pallial origin of a telencephalic NG2 population, which in the olfactory bulb is derived from local progenitors. Together, our results reveal an original ontogenic process that gives rise to the NG2-glia population and expands the previously established limits of development. © 2014 the authors.
URIhttp://hdl.handle.net/10261/155422
DOI10.1523/JNEUROSCI.3060-13.2014
Identificadoresdoi: 10.1523/JNEUROSCI.3060-13.2014
issn: 0270-6474
Aparece en las colecciones: (IC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Journal of Neuroscience.pdf5,6 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.