English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/155219
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Local Juvenile Hormone activity regulates gut homeostasis and tumor growth in adult Drosophila

AuthorsRahman, M. M.; Franch-Marro, Xavier ; Maestro, José L. ; Martín Casacuberta, David A. ; Casali, A.
Issue Date2017
PublisherNature Publishing Group
CitationScientific Reports 7: 11677 (2017)
AbstractHormones play essential roles during development and maintaining homeostasis in adult organisms, regulating a plethora of biological processes. Generally, hormones are secreted by glands and perform a systemic action. Here we show that Juvenile Hormones (JHs), insect sesquiterpenoids synthesized by the corpora allata, are also synthesized by the adult Drosophila gut. This local, gut specific JH activity, is synthesized by and acts on the intestinal stem cell and enteroblast populations, regulating their survival and cellular growth through the JH receptors Gce/Met and the coactivator Tai. Furthermore, we show that this local JH activity is important for damage response and is necessary for intestinal tumor growth driven by activating mutations in Wnt and EGFR/Ras pathways. Together, our results identify JHs as key hormonal regulators of gut homeostasis and open the possibility that analogous hormones may play a similar role in maintaining vertebrate adult intestinal stem cell population and sustaining tumor growth.
Publisher version (URL)http://doi.org/10.1038/s41598-017-11199-9
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
Rahman et al. 2017.pdf3,49 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.