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Título: | Changes in caprine milk oligosaccharides at different lactation stages analyzed by high performance liquid chromatography coupled to mass spectrometry |
Autor: | Martín-Ortiz, Andrea CSIC; Barile, Daniela; Salcedo, J.; Moreno, F. Javier CSIC ORCID ; Clemente, Alfonso CSIC ORCID; Ruiz-Matute, Ana I. CSIC ORCID ; Sanz, M. Luz CSIC ORCID | Palabras clave: | Lactation stages Hydrophilic interaction liquid chromatography Nanoflow liquid chromatography–quadrupole-time-of-flight mass spectrometry Goat milk oligosaccharides |
Fecha de publicación: | 2017 | Editor: | American Chemical Society | Citación: | Journal of Agricultural and Food Chemistry 65(17): 3523-3531 (2017) | Resumen: | Changes of the abundance of caprine milk oligosaccharides (CMO) at different lactation stages have been evaluated by hydrophilic interaction liquid chromatography coupled to mass spectrometry (HILIC-Q MS) and nanoflow liquid chromatography-quadrupole-time-of-flight mass spectrometry (nano-LC-Chip-QTOF MS). Eight major oligosaccharides (OS) were quantified at different lactation stages by HILIC-Q MS, while the use of nano-LC-Chip-QToF MS allowed expanding the study to forty-nine different OS by monitoring neutral non- and fucosylated species, as well as acidic species containing not only N-acetyl-neuraminic acid or N-glycolyl-neuraminic acid residues but also the combination of both sialic acids. Overall, the most abundant OS decreased with lactation time, whereas different trends were observed for minor OS. 6′-Sialyl-lactose was the most abundant acidic OS while galactosyl-lactose isomers were identified as the most abundant neutral OS. This is the first time that a comprehensive study regarding the changes of the abundance of CMO, both neutral and acidic, at different lactation stages is carried out. | Descripción: | PMCID: PMC5557284. | Versión del editor: | https://doi.org/10.1021/acs.jafc.6b05104 | URI: | http://hdl.handle.net/10261/155092 | DOI: | 10.1021/acs.jafc.6b05104 | Identificadores: | doi: 10.1021/acs.jafc.6b05104 e-issn: 1520-5118 issn: 0021-8561 |
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