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dc.contributor.authorOrozco-Castellanos, Luis Manuel-
dc.contributor.authorMarcos-Fernández, Ángel-
dc.contributor.authorAlonso Castro, Angel Josabad-
dc.contributor.authorGonzález-García, Gerardo-
dc.contributor.authorBáez-García, José Eduardo-
dc.contributor.authorRivera-Leyva, Julio Cesar-
dc.contributor.authorZapata-Morales, Juan Ramón-
dc.contributor.authorRuiz-Padilla, Alan Joel-
dc.identifierdoi: 10.1590/s2175-97902017000116144-
dc.identifierissn: 1984-8250-
dc.identifiere-issn: 2175-9790-
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences 53: 1-8 (2017)-
dc.description.abstractBioresorbable linear poly(ether-ester-urethane)s with different hydrophilic characteristics were synthesized from triblock copolymers of poly(¿-caprolactone)-poly(ethylene oxide)-poly(¿-caprolactone) (PCL-PEO) as macrodiols, and L-lysine diisocyanate (LDI) or hexamethylenediisocyanate (HDI) were used as the required diisocyanates. Macrodiols were obtained by ring-opening polymerization (ROP) of ¿-caprolactone (CL). Polyurethanes were synthesized by the reaction of the triblock copolymers with LDI or HDI in solution using stannous 2-ethylhexanoate as catalyst. Polyurethane tablets were fabricated and investigated as prospective drug delivery systems. The effect of the PEO content on the polymers¿ performance as drug carriers was evaluated. It was found that water provoked more swelling and erosion of polymers with higher contents of PEO. The hydrocortisone release profiles were analyzed using the Ritger-Peppas approximation. An anomalous release behaviour (values of n higher than 0.5) was found for most of the analyzed samples-
dc.description.sponsorshipWe acknowledge the financial support provided by the Consejo Nacional de Ciencia y Tecnología (CONACYT), México, Ministerio de Ciencia e Innovación (MAT2014-52644-R), Spain, and the Universidad de Guanajuato, México. Authors are indebted to Dr. Guillermo Mendoza-Diaz (Universidad de Guanajuato) for his helpful discussions. The authors thank Salvador López Morales (Instituto de Investigaciones en Materiales, UNAM) for GPC-MALLS analysis. The authors wish to thank the Directorate for Research Support and Postgraduate Programs at the University of Guanajuato for their support in the editing of the English-language version of this article.-
dc.publisherUniversidade de São Paulo-
dc.subjectDrug delivery-
dc.subjectBioresorbable polyurethanes-
dc.titleHydrocortisone release from tablets based on bioresorbable poly(ether-ester-urethane)s-
dc.description.versionPeer Reviewed-
dc.contributor.funderUniversidad de Guanajuato-
dc.contributor.funderConsejo Nacional de Ciencia y Tecnología (México)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
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