Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/154841
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Computational mechanistic study of thionation of carbonyl compounds with Lawesson's reagent |
Autor: | Legnani, Laura; Toma, L.; Caramella, Pierluigi; Chiacchio, Maria A.; Giofrè, S.; Delso, J. Ignacio CSIC ORCID; Tejero, Tomás CSIC ORCID; Merino, Pedro CSIC ORCID | Fecha de publicación: | 2016 | Editor: | American Chemical Society | Citación: | Journal of Organic Chemistry 81(17): 7733-7740 (2016) | Resumen: | The thionation reaction of carbonyl compounds with Lawesson's reagent (LR) has been studied using density functional theory methods and topological analyses. After dissociation of LR, the reaction takes place through a two-step mechanism involving (i) a concerted cycloaddition between one monomer and the carbonyl compound to form a four-membered intermediate and (ii) a cycloreversion leading to the thiocarbonyl derivative and phenyl(thioxo)phosphine oxide. Topological analyses confirmed the concertedness and asynchronicity of the process. The second step is the rate-limiting one, and the whole process resembles the currently accepted mechanism for the lithium salt-free Wittig reaction. No zwitterionic intermediates are formed during the reaction, although stabilizing electrostatic interactions are present in initial stages. Phenyl(thioxo)phosphine oxide formed in the thionation reaction is capable of performing a second thionation, although with energy barriers higher than the first one. The driving force of the thionation reactions is the formation of trimers from the resulting monomers. In agreement with experimental observations, the amides are the most reactive when compared with esters, aldehydes, and ketones and the reaction is slightly influenced by the polarity of the solvent. Whereas for amides and esters substituents have little effect, aldehydes and ketones are influenced by both steric and electronic effects. | Versión del editor: | https://doi.org/10.1021/acs.joc.6b01420 | URI: | http://hdl.handle.net/10261/154841 | DOI: | 10.1021/acs.joc.6b01420 | Identificadores: | doi: 10.1021/acs.joc.6b01420 e-issn: 1520-6904 issn: 0022-3263 |
Aparece en las colecciones: | (ISQCH) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Lawesson.pdf | 1,86 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
39
checked on 17-mar-2024
WEB OF SCIENCETM
Citations
38
checked on 23-feb-2024
Page view(s)
290
checked on 19-mar-2024
Download(s)
428
checked on 19-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.