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Group 11 complexes with amino acid derivatives: Synthesis and antitumoral studies

AutorOrtego, Lourdes ; Meireles, Margarida; Kasper, Cornelia; Laguna, Antonio ; Villacampa, M. Dolores ; Gimeno, M. Concepción
Palabras claveSilver(I)
Amino acid derivatives
Apoptosis
Gold(I)
Antitumor properties
Copper(I)
Fecha de publicación2016
EditorElsevier
CitaciónJournal of Inorganic Biochemistry 156: 133-144 (2016)
ResumenGold(I), gold(III), silver(I) and copper(I) complexes with modified amino acid esters and phosphine ligands have been prepared in order to test their cytotoxic activity. Two different phosphine fragments, PPh and PPhpy (py = pyridine), have been used. The amino acid esters have been modified by introducing an aromatic amine as pyridine that coordinates metal fragments through the nitrogen atom, giving complexes of the type [M(L)(PR)] or [AuCl(L)] (L = l-valine-N-(4-pyridylcarbonyl) methyl ester (L1), l-alanine-N-(4-pyridylcarbonyl) methyl ester (L2), l-phenylalanine-N-(4-pyridylcarbonyl) methyl-ester) (L3); M = Au(I), Ag(I), Cu(I), PR = PPh, PPhpy). The in vitro cytotoxic activity of metal complexes was tested against four tumor human cell lines and one tumor mouse cell line. A metabolic activity test (3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide, MTT) was used and IC values were compared with those obtained for cisplatin. Several complexes displayed significant cytotoxic activities. In order to determine whether antiproliferation and cell death are associated with apoptosis, NIH-3T3 cells were exposed to five selected complexes (Annexin V + FITC, PI) and analyzed by flow cytometry. These experiments showed that the mechanism by which the complexes inhibit cell proliferation inducing cell death in NIH-3T3 cells is mainly apoptotic.
URIhttp://hdl.handle.net/10261/154790
DOI10.1016/j.jinorgbio.2015.12.018
Identificadoresdoi: 10.1016/j.jinorgbio.2015.12.018
e-issn: 1873-3344
issn: 0162-0134
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