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Título

Peptide δ-turn: Literature survey and recent progress

AutorToniolo, Claudio; Crisma, Marco; Moretto, Alessandro; Peggion, Cristina; Formaggio, Fernando; Alemán, Carlos; Cativiela, Carlos ; Ramakrishnan, Chandrasekharan; Balaram, Padmanabhan
Palabras clavecis-amide
Peptides
Statistical analysis
X-ray diffraction
Conformational analysis
Fecha de publicación2015
EditorWiley-VCH
CitaciónChemistry - A European Journal 21(40): 13866-13877 (2015)
ResumenAmong the various types of α-peptide folding motifs, δ-turn, which requires a central cis-amide disposition, has been one of the least extensively investigated. In particular, this main-chain reversal topology has been studied in-depth neither in linear/cyclic peptides nor in proteins. This Minireview article assembles and critically analyzes relevant data from a literature survey on the δ-turn conformation in those compounds. Unpublished results from recent conformational energy calculations and a preliminary solution-state analysis on a small model peptide, currently ongoing in our laboratories, are also briefly outlined.
URIhttp://hdl.handle.net/10261/154770
DOI10.1002/chem.201501467
Identificadoresdoi: 10.1002/chem.201501467
e-issn: 1521-3765
issn: 0947-6539
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