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Título

Opiate activity of peptides derived from the three opioid peptide families on the rat vas deferens

AutorSánchez-Blázquez, Pilar ; Garzón, Javier ; Lee, N.M.; Hollt, V.
Fecha de publicación1984
EditorChurchill Livingstone
CitaciónNeuropeptides 5: 181- 184 (1984)
ResumenThe inhibitory activity of opioid peptides derived from pro-opiomelano-cortin (POMC), pro-enkephalin A and pro-enkephalin B (= pro-dynorphin) on the electrically evoked twitch of the rat vas deferens (RVD) was evaluated. The POMC-derived β-endorphin exhibits the greatest potency on this preparation. In addition, all peptides derived from pro-enkephalin A show full agonistic activity with BAM-22P and peptide E as the most potent peptides. In contrast, the majority of peptides derived from pro-enkephalin B (= pro-dynorphin) were essentially inactive on this tissue. Moreover, no antagonistic properties of these peptides were demonstrable in this preparation; thus the opioid receptors present in the RVD (putative epsilon receptors) might not possess any particular affinity for the pro-enkephalin B derived peptides.
URIhttp://hdl.handle.net/10261/154675
DOInull
Identificadoresdoi: null
issn: 0143-4179
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