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The genomic analysis of the Andaman islanders gives a new insight on the spread of modern humans in Asia

AuthorsMondal, Mayukh ; Basu, Analabha; Majumder, Partha P.; Casals, Ferran ; Bertranpetit, Jaume
Issue Date23-Jun-2015
CitationXV Jornada de Biología Evolutiva (2015)
AbstractAndamanese is a native-population living in Andaman Island, India. Andamanese and other “Negrito” populations in South-East Asia are phenotypically different from other Indian populations and resemble to African pygmies. Andamanese have been isolated from other populations with limited admixture with other populations. Thus they are a key population to study the dispersal of humans into South-East Asia. Using whole-genome-sequence data of Andamanese we tested (i) whether these populations share an origin with other Asian popula tions, (ii) quantify the presence of other ancient hominids in Andamanese, and (iii) how natural selection has shaped the genome of these populations. We generated whole*genome*sequence data of 10 individuals from Andaman islands, and 60 individuals from Mainland India. Using D-stat our analysis suggest: (i) Andamanese share a common ancestry with other Asian populations, originated in a single out of Africa expansion. (ii) They have similar amount of Neanderthal ancestry to other Out-of-Africa populations, though they lack Denisova ances try. We also find, in the Andaman genomes, traces of ancient genomes that are neither Neanderthal nor Denisovan. (iii) Selection have acted strongly on height related genes in Andamanese populations. Our findings suggest that Andamanese populations don’t have a different origin than other Asian populations,contrary to the hypothesis of a first Out-of-Africa that would populate the Andaman Islands, where they would remain, having been substituted in mainland Asia. Their phenotypical differences are mainly due to strong selection on specific type of genes (i.e. height) which might be the result of convergent-evolution producing the Negrito phenotype.
DescriptionTrabajo presentado en la XV Jornada de Biología Evolutiva, celebrada en Barcelona el 23 de junio de 2015.
Appears in Collections:(IBE) Comunicaciones congresos
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