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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/154152
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dc.contributor.authorHernansanz-Agustín, Pabloes_ES
dc.contributor.authorRamos, Edurnees_ES
dc.contributor.authorNavarro, Elisaes_ES
dc.contributor.authorParada, Estheres_ES
dc.contributor.authorMoreno Capellán, Lauraes_ES
dc.contributor.authorIzquierdo-Álvarez, Aliciaes_ES
dc.contributor.authorBuendía Abaitua, Izaskunes_ES
dc.contributor.authorCogolludo, Angeles_ES
dc.contributor.authorEgea Maiquez, Javieres_ES
dc.contributor.authorLópez, Manuela G.es_ES
dc.contributor.authorMartínez-Ruiz, Antonioes_ES
dc.date.accessioned2017-08-17T09:03:17Z-
dc.date.available2017-08-17T09:03:17Z-
dc.date.issued2016-
dc.identifier.citation3rd Symposium on Biomedical Research (2016)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/154152-
dc.descriptionResumen del póster presentado al 3rd Symposium on Biomedical Research: "Advances and Perspectives in Neuroscience", celebrado en la Universidad Autónoma de Madrid el 22 de abril de 2016.-- et al.es_ES
dc.description.abstractOxygen is a key molecule of aerobic life, but can give rise to reactive oxygen species (ROS) as metabolic byproducts of oxidative phosphorylation. Acute hypoxia produces a superoxide burst, which can signal downstream cell adaptations. Here we show that hypoxia triggers acute deactivation of mitochondrial complex I, changing its catalytic activity from an oxidoreductase to a Na+/H+ antiporter. The subsequent stimulation of mitochondrial Na+/Ca2+ exchanger (NCLX) activity promotes mitochondrial depolarization and superoxide production and underlies the participation of both complex I and NCLX in acute oxygen sensing. NCLX inhibition is associated with the suppression of downstream ROS-driven responses to hypoxia such as hypoxic pulmonary vasoconstriction, HIF-1α stabilization and ischemic brain damage in vivo. These results provide biological explanations for superoxide production in acute hypoxia and highlight complex I and NCLX as potential therapeutic targets in diseases involving mitochondrial ROS signalling, hypoxia and oxidative stress.es_ES
dc.language.isoenges_ES
dc.rightsclosedAccesses_ES
dc.titleReactive oxygen species production in acute hypoxia: oxygen sensing by mitochondrial complex I and the role of the sodium/calcium exchanger NCLXes_ES
dc.typepóster de congresoes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.csicSíes_ES
oprm.item.hasRevisionno ko 0 false*
dc.type.coarhttp://purl.org/coar/resource_type/c_6670es_ES
item.openairetypepóster de congreso-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
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