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Effect of thyroid hormone treatment in performance of socially and spatially dependent tasks by aging mice

AutorBaliyan, S.; Obregón, María Jesús; Venero, César
Fecha de publicación2016
Citación3rd Symposium on Biomedical Research (2016)
ResumenWith an increase in age, reduced levels of thyroid hormones (TH) are observed in mice, an event that may be related to age-related decline in spatial learning capabilities. In order to further explore this, the present study used two groups of aged male mice (19 months old). Treated animals, received TH (T3+T4) in drinking water, and controls. After 4 weeks of treatment, a battery of behavioural experiments was conducted specifically oriented to evaluate the effects of TH on anxiety, sociability and cognition in aged mice. In the elevated plus maze, no significant differences in anxiety related behaviour were observed between both groups. The results of the Barnes maze test revealed that TH treated aged mice visited a significantly lower number of false escape holes before arriving at the correct escape as compared to the number of attempts by the control group, indicating better spatial learning abilities in TH treated aged mice. In addition, differences were observed between treated and control groups in the sociability and social novelty tests, where treated mice spent significantly more time with the mouse vs the object and the novel conspecific vs the known conspecific. In order to follow the changes in TH levels over time, blood plasma samples were collected across days 0, 15, 30 and 60 of the experiment following which subjects were sacrificed and brain samples collected for an analysis of the T3 and T4 levels using radioimmunoassay. While treated mice showed significantly lower plasma T3 levels across days 15 & 30, this difference was reversed by day 60. Interestingly, at the end of the experiment, treated mice showed higher striatal T3 levels that positively correlated to the sociability indexes of the animals. Overall, the results indicate that TH treatment may be of therapeutical interest to prevent age-associated cognitive decline and low sociability.
DescripciónResumen del póster presentado al 3rd Symposium on Biomedical Research: "Advances and Perspectives in Neuroscience", celebrado en la Universidad Autónoma de Madrid el 22 de abril de 2016.
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