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Role of the redox signaling in self-renewal and multipotency of neural stem cells: implications in aging and Alzheimer´s Disease

AutorRobledinos-Antón, N.; Cuadrado, Antonio
Fecha de publicación2016
Citación3rd Symposium on Biomedical Research (2016)
ResumenAging involves a gradual loss of well-defined neuronal populations and neurogenic capacity. This age-dependent reduction in neurogenesis is worsened in neurodegenerative disorders, such as Alzheimer ́s disease (AD). In adult brain, neurogenesis persists in two germinal zones: subventricular zone (SVZ) of lateral wall of ventricle and subgranular zone (SGZ) in the dentate gyrus of hippocampus. Alterations in the microenvironment of neurogenic niches, like oxidative stress, have been related with the onset and progression of neurodegenerative diseases. One of the mechanisms to face these processes is the transcription factor Nrf2, master regulator of anti-oxidant and anti-inflammatory response. Here, we report the role of Nrf2 in the maintenance of neurogenic niches. We have developed animal models with the main anatomopathological and cognitive hallmarks of AD, expressing TAU(P301L) and APP(V717I) in combination with presence or absence of NRF2. Our data show a decrease in the neurogenic capacity with aging and that lack of NRF2 affects the proliferative capacity of neural stem cells and the cellular composition of the neurogenic niche of the dentate gyrus.
DescripciónResumen del póster presentado al 3rd Symposium on Biomedical Research: "Advances and Perspectives in Neuroscience", celebrado en la Universidad Autónoma de Madrid el 22 de abril de 2016.
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