Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/154108
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorVaran, Gamzees_ES
dc.contributor.authorBenito, Juan M.es_ES
dc.contributor.authorOrtiz-Mellet, Carmenes_ES
dc.contributor.authorBilensoy, Eremes_ES
dc.date.accessioned2017-08-16T08:43:27Z-
dc.date.available2017-08-16T08:43:27Z-
dc.date.issued2017-
dc.identifier.citationBeilstein Journal of Nanotechnology, 8, 1457–1468 (2017)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/154108-
dc.description.abstractBackground: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor aqueous solubility and tendency to recrystallize upon dilution, paclitaxel is commercially formulated with co-solvents such as Cremophor EL® that are known to cause serious side effects during chemotherapy. Amphiphilic cyclodextrins are favored oligosaccharides as drug delivery systems for anticancer drugs, having the ability to spontaneously form nanoparticles without surfactant or co-solvents. In the past few years, polycationic, amphiphilic cyclodextrins were introduced as effective agents for gene delivery in the form of nanoplexes. In this study, the potential of polycationic, amphiphilic cyclodextrin nanoparticles were evaluated in comparison to non-ionic amphiphilic cyclodextrins and core–shell type cyclodextrin nanoparticles for paclitaxel delivery to breast tumors. Pre-formulation studies were used as a basis for selecting the suitable organic solvent and surfactant concentration for the novel polycationic cyclodextrin nanoparticles. The nanoparticles were then extensively characterized with particle size distribution, polydispersity index, zeta potential, drug loading capacity, in vitro release profiles and cytotoxicity studies. Results: Paclitaxel-loaded cyclodextrin nanoparticles were obtained in the diameter range of 80−125 nm (depending on the nature of the cyclodextrin derivative) where the smallest diameter nanoparticles were obtained with polycationic (PC) βCDC6. A strong positive charge also helped to increase the loading capacity of the nanoparticles with paclitaxel up to 60%. Interestingly, cyclodextrin nanoparticles were able to stabilize paclitaxel in aqueous solution for 30 days. All blank cyclodextrin nanoparticles were demonstrated to be non-cytotoxic against L929 mouse fibroblast cell line. In addition, paclitaxel-loaded nanoparticles have a significant anticancer effect against MCF-7 human breast cancer cell line as compared with a paclitaxel solution in DMSO.Conclusion: According to the results of this study, both amphiphilic cyclodextrin derivatives provide suitable nanometer-sized drug delivery systems for safe and efficient intravenous paclitaxel delivery for chemotherapy. In the light of these studies, it can be said that amphiphilic cyclodextrin nanoparticles of different surface charge can be considered as a promising alternative for selfassembled nanometer-sized drug carrier systems for safe and efficient chemotherapyes_ES
dc.language.isoenges_ES
dc.publisherBeilstein-Institut für Literatur der Organischen Chemiees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectAmphiphilic cyclodextrin;es_ES
dc.subjectAnticanceres_ES
dc.subjectNanoparticleses_ES
dc.subjectPaclitaxeles_ES
dc.subjectPolycationices_ES
dc.titleDevelopment of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug deliveryes_ES
dc.typeartículoes_ES
dc.identifier.doi10.3762/bjnano.8.145-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhtpp://dx.doi.org/10.3762/bjnano.8.145es_ES
dc.rights.licenseCreative Commons Attribution License 4.0es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.pmid28900599-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
Aparece en las colecciones: (IIQ) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Benito.pdf2,01 MBAdobe PDFVista previa
Visualizar/Abrir
Show simple item record

CORE Recommender

PubMed Central
Citations

9
checked on 03-mar-2024

SCOPUSTM   
Citations

38
checked on 14-mar-2024

WEB OF SCIENCETM
Citations

35
checked on 23-feb-2024

Page view(s)

293
checked on 18-mar-2024

Download(s)

186
checked on 18-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.