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A substantial number of adaptive mutations are lost to Hill-Robertson Interference in Drosophila

AuthorsCastellano, David; Barrón, Maite G. ; Coronado, Marta; Campos, José; Barbadilla, Antonio; Eyre-Walker, Adam
Issue DateJul-2015
CitationAnnual meeting of the Society for Molecular Biology and Evolution (2015)
AbstractHill-Roberston interference is expected to reduce the number of adaptive substitutions in regions of the genome with low rates of recombination. To investigate this penomenon we have estimated the rate of adaptive amino acid substitution using a McDonald-Kreitman type approach that corrects for the influence of slightly deleterious mutations. We find that the rate of adaptive substitution is positively correlated to the rate of recombination but that the relationship is non-linear - the rate of adaptive evolution asymptotes. Using the observed relationship between rate of adaptive evolution and the rate of recombination we estimate that ~25% of advantageous mutations, which would oteherwise be destined for fixation, are lost through Hill-Robertson interference.
DescriptionTrabajo presentado en la Annual meeting of the Society for Molecular Biology and Evolution (SMBE 2015), celebrado en Viena del 12 al 16 de julio de 2015.
Appears in Collections:(IBE) Comunicaciones congresos
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