English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/153948
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

A substantial number of adaptive mutations are lost to Hill-Robertson Interference in Drosophila

AutorCastellano, David; Barrón, Maite G. ; Coronado, Marta; Campos, José; Barbadilla, Antonio; Eyre-Walker, Adam
Fecha de publicaciónjul-2015
CitaciónAnnual meeting of the Society for Molecular Biology and Evolution (2015)
ResumenHill-Roberston interference is expected to reduce the number of adaptive substitutions in regions of the genome with low rates of recombination. To investigate this penomenon we have estimated the rate of adaptive amino acid substitution using a McDonald-Kreitman type approach that corrects for the influence of slightly deleterious mutations. We find that the rate of adaptive substitution is positively correlated to the rate of recombination but that the relationship is non-linear - the rate of adaptive evolution asymptotes. Using the observed relationship between rate of adaptive evolution and the rate of recombination we estimate that ~25% of advantageous mutations, which would oteherwise be destined for fixation, are lost through Hill-Robertson interference.
DescripciónTrabajo presentado en la Annual meeting of the Society for Molecular Biology and Evolution (SMBE 2015), celebrado en Viena del 12 al 16 de julio de 2015.
URIhttp://hdl.handle.net/10261/153948
Aparece en las colecciones: (IBE) Comunicaciones congresos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.