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Título: | Insulin-like growth factor I is required for vessel modeling in the adult brain |
Autor: | López-López, Cristina CSIC; LeRoith, D.; Torres Alemán, Ignacio CSIC ORCID | Fecha de publicación: | 2004 | Editor: | National Academy of Sciences (U.S.) | Citación: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101: 9833- 9838 (2004) | Resumen: | Although vascular dysfunction is a major suspect in the etiology of several important neurodegenerative diseases, the signals involved in vessel homeostasis in the brain are still poorly understood. We have determined whether insulin-like growth factor I (IGF-I), a wide-spectrum growth factor with angiogenic actions, participates in vascular remodeling in the adult brain. IGF-I induces the growth of cultured brain endothelial cells through hypoxia-inducible factor 1α and vascular endothelial growth factor, a canonical angiogenic pathway. Furthermore, the systemic injection of IGF-I in adult mice increases brain vessel density. Physical exercise that stimulates widespread brain vessel growth in normal mice fails to do so in mice with low serum IGF-I. Brain injury that stimulates angiogenesis at the injury site also requires IGF-I to promote perilesion vessel growth, because blockade of IGF-I input by an anti-IGF-I abrogates vascular growth at the injury site. Thus, IGF-I participates in vessel remodeling in the adult brain. Low serum/brain IGF-I levels that are associated with old age and with several neurodegenerative diseases may be related to an increased risk of vascular dysfunction. | URI: | http://hdl.handle.net/10261/153916 | DOI: | 10.1073/pnas.0400337101 | Identificadores: | doi: 10.1073/pnas.0400337101 issn: 0027-8424 |
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