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dc.contributor.authorKong, N.-
dc.contributor.authorXie, S.-
dc.contributor.authorZhou, J.-
dc.contributor.authorMenéndez, Margarita-
dc.contributor.authorSolís, Dolores-
dc.contributor.authorPark, J.-
dc.contributor.authorRamström, O-
dc.contributor.authorYan, M-
dc.date.accessioned2017-08-07T09:50:58Z-
dc.date.available2017-08-07T09:50:58Z-
dc.date.issued2016-
dc.identifierdoi: 10.1021/acsami.6b07471-
dc.identifierissn: 1944-8252-
dc.identifier.citationACS Applied Materials and Interfaces 8: 28136- 28142 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/153900-
dc.description.abstractA new conjugation method for the immobilization of carbohydrates on nanomaterials was demonstrated simply by mixing perfluorophenyl azide-functionalized silica nanoparticles (SNPs), an amine-derivatized carbohydrate, and phenylacetaldehyde under ambient conditions without any catalyst. The density of carbohydrates on the glyconanoparticles was determined using the quantitative 19F NMR (19F qNMR) technique; for example, the density of D-mannose (Man) on Man-SNPs was 2.5 ± 0.2 × 10¿16 nmol/nm2. The glyconanoparticles retained their binding affinity and selectivity toward cognate lectins. The apparent dissociation constant of the glyconanoparticles was measured by a fluorescence competition assay, where the binding affinity of Man-SNPs was almost 4 orders of magnitude higher than that of Man with concanavalin A. Moreover, even with a ligand density of 2.6 times lower than Man-SNPs synthesized by the coppercatalyzed azide¿alkyne cycloaddition, the binding affinity of Man-SNPs prepared by the current method was more than 4 times higher. KEYWORDS: carbohydrates, glyconanomaterials, coupling-
dc.relationMINECO/ICTI2013-2016/BFU2015-70052-R-
dc.rightsclosedAccess-
dc.titleCatalyst-Free Cycloaddition Reaction for the Synthesis of Glyconanoparticles-
dc.typeartículo-
dc.identifier.doi10.1021/acsami.6b07471-
dc.date.updated2017-08-07T09:50:58Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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