English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/153801
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorMerenciano, Miriames_ES
dc.contributor.authorUllastres, Anaes_ES
dc.contributor.authorGonzález Pérez, Josefaes_ES
dc.date.accessioned2017-08-02T11:59:10Z-
dc.date.available2017-08-02T11:59:10Z-
dc.date.issued2016-04-
dc.identifier.citationInternational Congres on Transposable Elements (2016)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/153801-
dc.descriptionTrabajo presentado en el International Congres on Transposable Elements (ICTE 2016), celebrado en Saint Malo (Francia) del 16 al 19 de abril de 2016.es_ES
dc.description.abstractMutational hotspots are common in disease genes and in complex genomic regions not amenable to sequencing by short reads technologies. However, it is still not clear what makes a particular genomic region more prone to mutations and whether the different mutations located in a hotspot are functionally equivalent. In this work, we have discovered and characterized in detail an insertional hotspot in the promoter region of a stress-response gene in the fruitfly Drosophila melanogaster. The nine transposable elements insertions described are clustered in a small 368 bp region and all belong to the same family of transposable elements: the roo family. Although the sequences of these insertions are highly similar, their molecular and functional consequences are different: only FBti0019985 insertion is associated with increased resistance to coldstress. Interestingly, the previously described insertional hotspot in the D. melanogaster genome was also located in the promoter of a stress response gene suggesting that selection may favour the maintenance of genetic variability in these genes.es_ES
dc.language.isoenges_ES
dc.rightsclosedAccesses_ES
dc.titleFunctional analysis of a natural mutational hotspot in the proximal promoter of a stress-response gene in Drosophilaes_ES
dc.typepóster de congresoes_ES
dc.description.peerreviewedNoes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
Appears in Collections:(IBE) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.