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dc.contributor.authorMerenciano, Miriames_ES
dc.contributor.authorUllastres, Anaes_ES
dc.contributor.authorGonzález Pérez, Josefaes_ES
dc.identifier.citationInternational Congres on Transposable Elements (2016)es_ES
dc.descriptionTrabajo presentado en el International Congres on Transposable Elements (ICTE 2016), celebrado en Saint Malo (Francia) del 16 al 19 de abril de 2016.es_ES
dc.description.abstractMutational hotspots are common in disease genes and in complex genomic regions not amenable to sequencing by short reads technologies. However, it is still not clear what makes a particular genomic region more prone to mutations and whether the different mutations located in a hotspot are functionally equivalent. In this work, we have discovered and characterized in detail an insertional hotspot in the promoter region of a stress-response gene in the fruitfly Drosophila melanogaster. The nine transposable elements insertions described are clustered in a small 368 bp region and all belong to the same family of transposable elements: the roo family. Although the sequences of these insertions are highly similar, their molecular and functional consequences are different: only FBti0019985 insertion is associated with increased resistance to coldstress. Interestingly, the previously described insertional hotspot in the D. melanogaster genome was also located in the promoter of a stress response gene suggesting that selection may favour the maintenance of genetic variability in these genes.es_ES
dc.titleFunctional analysis of a natural mutational hotspot in the proximal promoter of a stress-response gene in Drosophilaes_ES
dc.typepóster de congresoes_ES
oprm.item.hasRevisionno ko 0 false*
Appears in Collections:(IBE) Comunicaciones congresos
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