English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/153797
Título

Breast Milk Polyamines and Microbiota Interactions: Impact of Mode of Delivery and Geographical Location

AutorGómez-Gallego, Carlos; Kumar, Himanshu; García Mantrana, Izaskun ; du Toit, Elloise; Suomela, Jukka‐Pekka; Linderborg, Kaisa M.; Zhang, Yumei; Isolauri, Erika; Yang, Baoru; Salminen, Seppo; Collado, María Carmen
Palabras clavePolyamines
Putrescine
Spermidine
Spermine
Caesarean
Breast milk
Microbiota
Proteobacteria
Fecha de publicación17-mar-2017
EditorS. Karger AG
CitaciónAnnals of Nutrition and Metabolism 70:184-190 (2017)
ResumenBackground/Aims: The aim of the present study was to identify and quantify the polyamine levels in human milk obtained from different countries and through different modes of delivery, and to investigate their association with breast milk microbes. Methods: Mature breast milk samples were obtained from 78 healthy mothers after 1 month of lactation from 4 different geographical locations: Finland, Spain (Europe); South Africa (Africa); and China (Asia). Polyamines were determined using HPLC after dansyl derivatization and milk microbiota was obtained by 16S rRNA gene sequencing. Results: The mean values of polyamines in breast milk were 70.0, 424.2, and 610.0 nmol/dL for putrescine, spermidine and spermine, respectively, and 1,170.9 nmol/dL of total polyamines. The levels of putrescine were significantly higher in Spain (p < 0.05) and spermidine levels were significantly higher in Finland (p < 0.05) compared with other countries. Cesarean delivery had an impact on polyamine levels and it was related to an increase in the putrescine concentration being significant in Spanish samples (p < 0.01). Furthermore, putrescine levels were correlated positively with Gammaproteobacteria (r = 0.46, p < 0.001), especially with Pseudomonas fragi (r = 0.40, p < 0.001). Conclusions: The results demonstrate significant effect of geographical variations in human milk polyamine concentrations, being correlated with human milk microbiota composition. These differences may have an impact on infant development during lactation.
DescripciónThis is the peer-reviewed but unedited manuscript version of the following article: Ann Nutr Metab 2017;70:184-190 (DOI: 110.1159/000457134) The final, published version is available at http://www.karger.com/?doi=10.1159/000457134
Versión del editorhttps://doi.org/10.1159/000457134
URIhttp://hdl.handle.net/10261/153797
DOI10.1159/000457134
ISSN0250-6807
Aparece en las colecciones: (IATA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Annals Nutr Metab-2017_Gomez-Gallego.pdfArtículo principal183,12 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.