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Título: | Targeting insulin-like growth factor-1 to treat Alzheimer's disease |
Autor: | Torres Alemán, Ignacio CSIC ORCID | Palabras clave: | Alzheimer's disease Amyloidosis Cognitive loss Insulin-like growth factor I Tauopathy | Fecha de publicación: | 2007 | Editor: | Ashley Publications | Citación: | Expert Opinion on Therapeutic Targets 11: 1535- 1542 (2007) | Resumen: | The 'amyloid cascade hypothesis' proposes that disturbances in amyloid metabolism cause Alzheimer's disease (AD). However, a comprehensive explanation of the mechanisms leading to brain amyloidosis is still pending. Building on previous findings with insulin, and recent observations with insulin-like growth factor-1 (IGF-1) in AD pathology, new evidence suggests that the interaction of environmental factors and inheritance lead to abnormally reduced input/traffic of serum IGF-1 at the blood-brain barriers. The resultant deterioration in brain IGF-1 function may originate all the pathological changes observed in late-onset AD. These include cognitive loss, abnormal amyloid metabolism and aberrant Tau phosphorylation, as well as disturbances, such as inflammation, oxidative stress or mitochondrial dysfunction, among others. A better understanding of the role of IGF-1 in all these perturbations is required, particularly in relation to cognition. Furthermore, insight into the environmental factors contributing to abnormally reduced IGF-1 function in AD brains may become crucial in development of much needed disease-modifying strategies. © 2007 Informa UK Ltd. | URI: | http://hdl.handle.net/10261/153747 | DOI: | 10.1517/14728222.11.12.1535 | Identificadores: | doi: 10.1517/14728222.11.12.1535 issn: 1472-8222 |
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