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Cannabinoids derivatives modify the pattern of sphingolipids in acute myeloid leukemia cells and produce a potent anti-leukemic effect

AuthorsMedrano Domínguez, Mayte; Barbado, Victoria; Campillo, Nuria E. ; Hidalgo Casado, Francisco ; Caballero, T.; Álvarez Laderas, Isabel; Óscar, López; Piruat, José I.; Pérez-Simón, José A.
Issue Date26-Jun-2017
PublisherFerrata Storti Foundation
Citationhaematologica 102(s2)208 (2017)
AbstractEndocannabinoid system is a set of ligands, receptors and endogenous enzymes which modulate a variety of physiological effects. There are two well-characterized cannabinoid receptors, CB1 (mainly expressed in Central Nervous System) and CB2 (mainly in hematopoietic cells). Here, we tested the effect of the cannabinoid WIN-55 212-2 in acute myeloid leukemia (AML) in vitro and in vivo and studied the molecular signaling pathways involved in this effect, specially the role of sphingolipids. Moreover, we synthesized a new family of twelve cannabinoids that are specific to CB2 receptor.
Description2 p. 22nd Congress of the European Hematology Association. Madrid, Spain, June 22 - 25, 2017
Publisher version (URL)http://www.haematologica.org/content/102/s2
Appears in Collections:(CIB) Comunicaciones congresos
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