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Título: | Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration |
Autor: | Ramos, E.; Egea, Javier; Rios, C. de los; Marco-Contelles, José CSIC ORCID; Romero, A. | Palabras clave: | Melatonin Hybrid compounds MTDLs Multitarget-directed ligands Neurodegeneration Alzheimer's disease Antioxidant therapy |
Fecha de publicación: | 2017 | Editor: | Future Science | Citación: | Future Medicinal Chemistry 9: 765- 780 (2017) | Resumen: | Melatonin is an indoleamine produced mainly in the pineal gland. The natural decline of melatonin levels with aging strongly contributes to the development of neurodegenerative disorders. Pleiotropic actions displayed by melatonin prevent several processes involved in neurodegeneration such as neuroinflammation, oxidative stress, excitotoxicity and/or apoptosis. This review focuses on a number of melatonin hybrids resulting from the juxtaposition of tacrine, berberine, tamoxifen, curcumin, N,N-dibenzyl(N-methyl)amine, among others, with potential therapeutic effects for the treatment of neurodegenerative diseases. | Versión del editor: | http://dx.doi.org/10.4155/fmc-2017-0014 | URI: | http://hdl.handle.net/10261/153626 | DOI: | 10.4155/fmc-2017-0014 | Identificadores: | doi: 10.4155/fmc-2017-0014 issn: 1756-8919 e-issn: 1756-8927 |
Aparece en las colecciones: | (IQM) Artículos (IQOG) Artículos |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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