Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/153599
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Comparative Transcriptome Analysis of Human Trophectoderm and Embryonic Stem Cell-Derived Trophoblasts Reveal Key Participants in Early Implantation

AutorAghajanova, Lusine; Shen, Shehua; Rojas Álvarez-Ossorio, M. Ángeles CSIC ORCID; Fisher, Susan J.; Irwin, Juan C.; Giudice, Linda C.
Palabras claveEmbryonic stem cells (ESCs)
Human embryonic stem cells
Differentiation
Secretome
Transcriptomes
Trophectoderm
Trophoblast
Fecha de publicación1-ene-2012
EditorOxford University Press
CitaciónBiology of Reproduction 86(1): 1-21 (2012)
ResumenTheimplantation process begins with attachment of the trophectoderm (TE) of the blastocyst to the maternal endometrial epithelium. Herein we have investigated the transcriptome of mural TE cells from 13 human blastocysts and compared these with those of human embryonic stem cell (hESC)-derived-TE (hESCtroph). The transcriptomes of hESCtroph at Days 8, 10, and 12 had the greatest consistency with TE. Among genes coding for secreted proteins of the TE of human blastocysts and of hESCtroph are several molecules known to be involved in the implantation process, as well as novel ones, such as CXCL12, HBEGF, inhibin A, DKK3, WNT5A, and follistatin. The similarities between the two lineages underscore some of the known mechanisms and offer discovery of new mechanisms and players in the process of the very early stages of human implantation. We propose that the hESCtroph is a viable functional model of human trophoblasts to study trophoblast-endometrial interactions. Furthermore, the data derived herein offer the promise of novel diagnostics and therapeutics aimed at practical challenges in human infertility and pregnancy disorders associated with abnormal embryonic implantation.
Versión del editorhttps://doi.org/10.1095/biolreprod.111.092775
URIhttp://hdl.handle.net/10261/153599
DOI10.1095/biolreprod.111.092775
ISSN0006-3363
E-ISSN1529-7268
Aparece en las colecciones: (IBIS) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

55
checked on 19-mar-2024

WEB OF SCIENCETM
Citations

45
checked on 29-feb-2024

Page view(s)

240
checked on 28-mar-2024

Download(s)

85
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.