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Troponin-I enhances and is required for oncogenic overgrowth

AutorCasas-Tinto, S.; Maraver, A.; Serrano, M.; Ferrús, Alberto
Palabras claveDrosophila Cancer Cell competition Cell proliferation
Fecha de publicación2016
CitaciónOncotarget 7: 52631- 52642 (2016)
ResumenHuman tumors of various tissue origins show an intriguing over-expression of genes not considered oncogenes, such as that encoding Troponin-I (TnI), a wellknown muscle protein. Out of the three TnI genes known in humans, the slow form, TNNI1, is affected the most. Drosophila has only one TnI gene, wupA. Here, we studied excess- and loss-of function of wupA in Drosophila, and assayed TNNI1 down regulation in human tumors growing in mice. Drosophila TnI excess-of-function increases proliferation and potentiates oncogenic mutations in Ras, Notch and Lgl genes. By contrast, TnI loss-of-function reduces proliferation and antagonizes the overgrowth due to these oncogenic mutations. Troponin-I defective cells undergo Flower- and Sparc-dependent cell competition. TnI can localize to the nucleus and its excess elicits transcriptional up-regulation of InR, Rap1 and Dilp8, which is consistent with the increased cell proliferation. Human tumor cell lines treated with a human Troponin-I peptide arrest in G/G. In addition, proliferation of non-smallcell lung carcinoma xenografts in mice is restrained by TNNI1 down-regulation. Thus, Troponin-I reveals a novel function in cell proliferation that may be of therapeutic interest in certain types of cancer.
URIhttp://hdl.handle.net/10261/153533
DOI10.18632/oncotarget.10616
Identificadoresdoi: 10.18632/oncotarget.10616
issn: 1949-2553
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