English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/153233
Título

The genome of the vervet (Chlorocebus aethiops sabaeus)

AutorWarren, Wesley C.; García-Pérez, Raquel; Marqués-Bonet, Tomàs ; Freimer, Nelson B.
Fecha de publicación2015
EditorCold Spring Harbor Laboratory. Press
CitaciónGenome Research 25: 1921-1933 (2015)
ResumenWe describe a genome reference of the African green monkey or vervet (Chlorocebus aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for genetic investigations of simian immunodeficiency virus (SIV), for which it is the most abundant natural host species, and of a wide range of health-related phenotypes assessed in Caribbean vervets (C. a. sabaeus), whose numbers have expanded dramatically since Europeans introduced small numbers of their ancestors from West Africa during the colonial era. We use the reference to characterize the genomic relationship between vervets and other primates, the intra-generic phylogeny of vervet subspecies, and genome-wide structural variations of a pedigreed C. a. sabaeus population. Through comparative analyses with human and rhesus macaque, we characterize at high resolution the unique chromosomal fission events that differentiate the vervets and their close relatives from most other catarrhine primates, in whom karyotype is highly conserved. We also provide a summary of transposable elements and contrast these with the rhesus macaque and human. Analysis of sequenced genomes representing each of the main vervet subspecies supports previously hypothesized relationships between these populations, which range across most of sub-Saharan Africa, while uncovering high levels of genetic diversity within each. Sequence-based analyses of major histocompatibility complex (MHC) polymorphisms reveal extremely low diversity in Caribbean C. a. sabaeus vervets, compared to vervets from putatively ancestral West African regions. In the C. a. sabaeus research population, we discover the first structural variations that are, in some cases, predicted to have a deleterious effect; future studies will determine the phenotypic impact of these variations.
DescripciónWarren, Wesley C. et al.
Versión del editorhttp://doi.org/10.1101/gr.192922.115
URIhttp://hdl.handle.net/10261/153233
DOI10.1101/gr.192922.115
ISSN1088-9051
E-ISSN1549-5469
Aparece en las colecciones: (IBE) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Genome Res.-2015-Warren-1921-33.pdf589,08 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.