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http://hdl.handle.net/10261/153093
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dc.contributor.author | Calderón‐Domínguez, María | - |
dc.contributor.author | Escoté, Xavier | - |
dc.contributor.author | Gómez-Serrano, María | - |
dc.contributor.author | Peral, Belén | - |
dc.contributor.author | Fernández-Veledo, Sonia | - |
dc.contributor.author | Vázquez-Carrera, Manuel | - |
dc.contributor.author | Villaroya, Francesc | - |
dc.contributor.author | Vendrell, Joan | - |
dc.contributor.author | Herrero, Laura | - |
dc.date.accessioned | 2017-07-14T12:16:47Z | - |
dc.date.available | 2017-07-14T12:16:47Z | - |
dc.date.issued | 2015 | - |
dc.identifier | doi: 10.1152/ajpendo.00362.2014 | - |
dc.identifier | issn: 0193-1849 | - |
dc.identifier | e-issn: 1522-1555 | - |
dc.identifier.citation | AJP - Endocrinology and Metabolism 308(9): E756-E769 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/153093 | - |
dc.description.abstract | Lipid overload in obesity and type 2 diabetes is associated with adipocyte dysfunction, inflammation, macrophage infiltration, and decreased fatty acid oxidation (FAO). Here, we report that the expression of carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme in mitochondrial FAO, is higher in human adipose tissue macrophages than in adipocytes and that it is differentially expressed in visceral vs. subcutaneous adipose tissue in both an obese and a type 2 diabetes cohort. These observations led us to further investigate the potential role of CPT1A in adipocytes and macrophages. We expressed CPT1AM, a permanently active mutant form of CPT1A, in 3T3-L1 CAR¿1 adipocytes and RAW 264.7 macrophages through adenoviral infection. Enhanced FAO in palmitate-incubated adipocytes and macrophages reduced triglyceride content and inflammation, improved insulin sensitivity in adipocytes, and reduced endoplasmic reticulum stress and ROS damage in macrophages. We conclude that increasing FAO in adipocytes and macrophages improves palmitate-induced derangements. This indicates that enhancing FAO in metabolically relevant cells such as adipocytes and macrophages may be a promising strategy for the treatment of chronic inflammatory pathologies such as obesity and type 2 diabetes. | - |
dc.description.sponsorship | This study was supported by the Spanish Ministry of Science and Innovation (Grants SAF2010-20039 and SAF2013-45887-R to L. Herrero, SAF2011-30520-C02-01 to D. Serra, PI11/00085 to J. J. Vendrell, SAF2012-33014 to B. Peral, SAF2012-36186 to S. Fernández-Veledo, SAF2012-30708 to M. Vázquez-Carrera, SAF2011-23626 to F. Villarroya, and doctoral fellowships to M. I. Malandrino and J. F. Mir), by the CIBER Fisiopatología de la Obesidad y la Nutrición (Grant CB06/03/0001 to D. Serra), and CIBER Diabetes y Enfermedades Metabólicas Asociadas (Grant CB07/08/0003 to M. Vázquez-Carrera), Instituto de Salud Carlos III, by the European Union (BetaBat project FP7-277713 to F. Villarroya), by the European Foundation for the Study of Diabetes (EFSD)/Lilly and EFSD/Janssen-Rising Star research fellowships to L. Herrero, and by a L’Oréal-UNESCO “For Women in Science” research fellowship to L. Herrero. S. Fernández-Veledo acknowledges support from the “Miguel Servet” tenure track program (CP10/00438) from the Fondo de Investigación Sanitaria and cofinanced by the European Regional Development Fund. M. Weber is a recipient of the Ciência sem Fronteiras-CNPq fellowship (237976/2012-9). | - |
dc.publisher | American Physiological Society | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/277713 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-45887-R | - |
dc.rights | closedAccess | - |
dc.title | Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1152/ajpendo.00362.2014 | - |
dc.date.updated | 2017-07-14T12:16:47Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España) | - |
dc.contributor.funder | Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (España) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | European Foundation for the Study of Diabetes | - |
dc.contributor.funder | United Nations Educational, Scientific and Cultural Organization | - |
dc.contributor.funder | Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001648 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100005243 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003593 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
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