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Title

Presynaptic Adenosine Receptor-Mediated Regulation of Diverse Thalamocortical Short-Term Plasticity in the Mouse Whisker Pathway

AuthorsFerrati, Giovanni; Martini, Francisco J.; Maravall, Miguel
Issue Date23-Feb-2016
PublisherFrontiers Media
CitationFront. Neural Circuits 10: 9 (2016)
AbstractShort-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits. In “driver” thalamocortical (TC) synaptic populations, STP is dominated by depression during stimulation from rest. However, during ongoing stimulation, lemniscal TC connections onto layer 4 neurons in mouse barrel cortex express variable STP. Each synapse responds to input trains with a distinct pattern of depression or facilitation around its mean steady-state response. As a result, in common with other synaptic populations, lemniscal TC synapses express diverse rather than uniform dynamics, allowing for a rich representation of temporally varying stimuli. Here, we show that this STP diversity is regulated presynaptically. Presynaptic adenosine receptors of the A1R type, but not kainate receptors (KARs), modulate STP behavior. Blocking the receptors does not eliminate diversity, indicating that diversity is related to heterogeneous expression of multiple mechanisms in the pathway from presynaptic calcium influx to neurotransmitter release.
Publisher version (URL)http://dx.doi.org/10.3389/fncir.2016.00009
URIhttp://hdl.handle.net/10261/152925
DOI10.3389/fncir.2016.00009
ISSN1662-5110
Appears in Collections:(IN) Artículos
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