Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/152911
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The Ever-Changing Morphology of Hippocampal Granule Neurons in Physiology and Pathology |
Autor: | Llorens-Martín, María CSIC ORCID ; Rábano, Alberto; Ávila, Jesús CSIC ORCID | Fecha de publicación: | 19-ene-2016 | Editor: | Frontiers Media | Citación: | Frontiers in Neuroscience 9: 526 (2016) | Resumen: | Newborn neurons are continuously added to the hippocampal dentate gyrus throughout adulthood. In this review, we analyze the maturational stages that newborn granule neurons go through, with a focus on their unique morphological features during each stage under both physiological and pathological circumstances. In addition, the influence of deleterious (such as schizophrenia, stress, Alzheimer's disease, seizures, stroke, inflammation, dietary deficiencies, or the consumption of drugs of abuse or toxic substances) and neuroprotective (physical exercise and environmental enrichment) stimuli on the maturation of these cells will be examined. Finally, the regulation of this process by proteins involved in neurodegenerative and neurological disorders such as Glycogen synthase kinase 3β, Disrupted in Schizophrenia 1 (DISC-1), Glucocorticoid receptor, pro-inflammatory mediators, Presenilin-1, Amyloid precursor protein, Cyclin-dependent kinase 5 (CDK5), among others, will be evaluated. Given the recently acquired relevance of the dendritic branch as a functional synaptic unit required for memory storage, a full understanding of the morphological alterations observed in newborn neurons may have important consequences for the prevention and treatment of the cognitive and affective alterations that evolve in conjunction with impaired adult hippocampal neurogenesis. | Versión del editor: | http://dx.doi.org/10.3389/fnins.2015.00526 | URI: | http://hdl.handle.net/10261/152911 | DOI: | 10.3389/fnins.2015.00526 | ISSN: | 1662-4548 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
The Ever-Changing Morphology.pdf | 5,08 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
23
checked on 24-abr-2024
SCOPUSTM
Citations
35
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
33
checked on 26-feb-2024
Page view(s)
246
checked on 23-abr-2024
Download(s)
175
checked on 23-abr-2024