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Title

Non-coding RNA regulation in pathogenic bacteria located inside eukaryotic cells

AuthorsOrtega, Álvaro D.; Quereda, Juan J.; Pucciarelli, María Graciela ; García del Portillo, Francisco
Issue Date12-Nov-2014
PublisherFrontiers Media
CitationFrontiers in Cellular and Infection Microbiology 4:162 (2014)
AbstractIntracellular bacterial pathogens have evolved distinct lifestyles inside eukaryotic cells. Some pathogens coexist with the infected cell in an obligate intracellular state, whereas others transit between the extracellular and intracellular environment. Adaptation to these intracellular lifestyles is regulated in both space and time. Non-coding small RNAs (sRNAs) are post-transcriptional regulatory molecules that fine-tune important processes in bacterial physiology including cell envelope architecture, intermediate metabolism, bacterial communication, biofilm formation, and virulence. Recent studies have shown production of defined sRNA species by intracellular bacteria located inside eukaryotic cells. The molecules targeted by these sRNAs and their expression dynamics along the intracellular infection cycle remain, however, poorly characterized. Technical difficulties linked to the isolation of “intact” intracellular bacteria from infected host cells might explain why sRNA regulation in these specialized pathogens is still a largely unexplored field. Transition from the extracellular to the intracellular lifestyle provides an ideal scenario in which regulatory sRNAs are intended to participate; so much work must be done in this direction. This review focuses on sRNAs expressed by intracellular bacterial pathogens during the infection of eukaryotic cells, strategies used with these pathogens to identify sRNAs required for virulence, and the experimental technical challenges associated to this type of studies. We also discuss varied techniques for their potential application to study RNA regulation in intracellular bacterial infections.
Publisher version (URL)http://dx.doi.org/10.3389/fcimb.2014.00162
URIhttp://hdl.handle.net/10261/152806
DOI10.3389/fcimb.2014.00162
ISSN2235-2988
Appears in Collections:(CNB) Artículos
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