Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/152558
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
DC FieldValueLanguage
dc.contributor.authorArauna, Laura R.es_ES
dc.contributor.authorMendoza-Revilla, Javieres_ES
dc.contributor.authorMas-Sandoval, Alexes_ES
dc.contributor.authorIzaabel, Hassanes_ES
dc.contributor.authorBekada, Asmahanes_ES
dc.contributor.authorBenhamamouch, Sorayaes_ES
dc.contributor.authorFadhlaoui-Zid, Karimaes_ES
dc.contributor.authorZalloua, Pierrees_ES
dc.contributor.authorHellenthal, Garrettes_ES
dc.contributor.authorComas, Davides_ES
dc.date.accessioned2017-07-10T11:51:27Z-
dc.date.available2017-07-10T11:51:27Z-
dc.date.issued2017-02-
dc.identifier.citationMolecular Biology and Evolution 34(2): 318-329 (2017)es_ES
dc.identifier.issn0737-4038-
dc.identifier.urihttp://hdl.handle.net/10261/152558-
dc.description.abstractNorth Africa is characterized by its diverse cultural and linguistic groups and its genetic heterogeneity. Genomic data has shown an amalgam of components mixed since pre-Holocean times. Though no differences have been found in uniparental and classical markers between Berbers and Arabs, the two main ethnic groups in the region, the scanty genomic data available have highlighted the singularity of Berbers. We characterize the genetic heterogeneity of North African groups, focusing on the putative differences of Berbers and Arabs, and estimate migration dates. We analyze genome-wide autosomal data in five Berber and six Arab groups, and compare them to Middle Easterns, sub-Saharans, and Europeans. Haplotype-based methods show a lack of correlation between geographical and genetic populations, and a high degree of genetic heterogeneity, without strong differences between Berbers and Arabs. Berbers enclose genetically diverse groups, from isolated endogamous groups with high autochthonous component frequencies, large homozygosity runs and low effective population sizes, to admixed groups with high frequencies of sub-Saharan and Middle Eastern components. Admixture time estimates show a complex pattern of recent historical migrations, with a peak around the 7th century C.E. coincident with the Arabization of the region; sub-Saharan migrations since the 1st century B.C. in agreement with Roman slave trade; and a strong migration in the 17th century C.E., coincident with a huge impact of the trans-Atlantic and trans-Saharan trade of sub-Saharan slaves in the Modern Era. The genetic complexity found should be taken into account when selecting reference groups in population genetics and biomedical studies.es_ES
dc.description.sponsorshipThis work was supported by the Spanish MINECO grants CGL2013-44351-P and the “María de Maeztu” Program for Units of Excellence in R&D (MDM-2014-0370); and the Generalitat de Catalunya grant 2014SGR866.es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.relationMINECO/ICTI2013-2016/CGL2013-44351-Pes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectPopulation geneticses_ES
dc.subjectNorth Africaes_ES
dc.subjectGenome wide SNPses_ES
dc.subjectBerberses_ES
dc.subjectHaplotypees_ES
dc.subjectAdmixtureses_ES
dc.titleRecent Historical Migrations Have Shaped the Gene Pool of Arabs and Berbers in North Africaes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1093/molbev/msw218-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1093/molbev/msw218es_ES
dc.identifier.e-issn1537-1719-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
dc.identifier.pmid27744413-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairetypeartículo-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat
msw218.pdf837,3 kBAdobe PDFThumbnail
View/Open
Show simple item record

PubMed Central
Citations

22
checked on Jan 19, 2022

SCOPUSTM   
Citations

37
checked on Jan 28, 2022

WEB OF SCIENCETM
Citations

35
checked on Jan 28, 2022

Page view(s)

325
checked on Jan 29, 2022

Download(s)

648
checked on Jan 29, 2022

Google ScholarTM

Check

Altmetric

Dimensions


Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.