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Thyroid hormone and the development of the brain

AuthorsBernal, Juan ; Guadaño-Ferraz, Ana
Issue Date1998
PublisherLippincott Williams & Wilkins
CitationCurrent Opinion in Endocrinology and Diabetes 5(4): 296-302 (1998)
AbstractThyroid hormone is an epigenetic factor in brain maturation. Its role is to synchronize developmental events by modulating the expression of already transcribed genes in a time- and region-dependent fashion. The genes regulated by thyroid hormone do not belong to a single functional category. Some of them are likely to represent primary actions of the hormone exerted directly at the genomic level. Others may be secondary to a more general effect on cell differentiation. Most of the genes are only transiently affected by hypothyroidism and thyroid hormone treatment during a critical period. Several questions remain unanswered, such as the role of specific thyroid hormone receptor isoforms and the molecular basis for the time window and the region-specific control of gene expression.
Identifiersissn: 1068-3097
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