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Título

Why fatty liver does not respond to isquemic preconditioning?

AutorMonsalve, María
Fecha de publicación2012
CitaciónIUBMB-FEBS 2012
ResumenThe number of donor livers is insufficient to cover the needs for liver transplants, which drives the use of suboptimal livers, like those that have an important accumulation of fat (fatty liver/steatotic liver). The steatosis makes the liver more sensitive to the damage that results from the isquemia-reperfusion (I/R) process, but also makes it less responsive to preconditioning protocols that normally make the livers more resistant to I/R damage. Our study shows that the activation of the transcriptional coactivator PGC-1 alpha, in response to I/R, is necessary to protect the liver from I/R damage and mediates the activation of protection mechanisms following the isquemic preconditioning protocol. It also suggest that the reduced activity of PGC-1 alpha in the steatotic liver could be responsible for its increased sensitivity to I/R damage and poor response to preconditioning protocols. These observations allow us to propose PGC-1 alpha as a relevant therapeutic target whose activation in the donor livers could facilitate the clinical use of steatotic livers for transplantation.
DescripciónResumen del trabajo presentado al 22nd Congres IUBMB and 37th Congress FEBS: "From Single Molecules to Systems Biology", celebrados en Sevilla (España) del 4 al 9 de septiembre de 2012.
URIhttp://hdl.handle.net/10261/152360
Aparece en las colecciones: (IIBM) Comunicaciones congresos
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