Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/152340
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Adaptive downregulation of pheomelanin-related Slc7a11 gene expression by environmentally induced oxidative stress

AuthorsGalván, Ismael CSIC ORCID ; Inácio, Ângela; Romero-Haro, Ana A. CSIC ORCID; Alonso-Álvarez, Carlos CSIC ORCID
KeywordsPigmentation
Oxidative stress
Pheomelanin
Environmental epigenetics
Slc7a11
Issue Date2017
PublisherJohn Wiley & Sons
CitationMolecular Ecology 26(3): 849-858 (2017)
AbstractPheomelanin is a sulphur-containing yellow-to-reddish pigment whose synthesis consumes the main intracellular antioxidant (glutathione; GSH) and its precursor cysteine. Cysteine used for pheomelanogenesis cannot be used for antioxidant protection. We tested whether the expression of Slc7a11, the gene regulating the transport of cysteine to melanocytes for pheomelanogenesis, is environmentally influenced when cysteine/GSH are most required for antioxidant protection. We found that zebra finches Taeniopygia guttata developing pheomelanin-pigmented feathers during a 12-day exposure to the pro-oxidant diquat dibromide downregulated the expression of Slc7a11 in feather melanocytes, but not the expression of other genes that affect pheomelanogenesis by mechanisms different from cysteine transport such as MC1R and Slc45a2. Accordingly, diquat-treated birds did not suffer increased oxidative stress. This indicates that some animals have evolved an adaptive epigenetic lability that avoids damage derived from pheomelanogenesis. This mechanism should be explored in human Slc7a11 to help combat some cancer types related to cysteine consumption.
URIhttp://hdl.handle.net/10261/152340
DOI10.1111/mec.13952
Identifiersdoi: 10.1111/mec.13952
issn: 1365-294X
Appears in Collections:(EBD) Artículos
(IREC) Artículos
(MNCN) Artículos

Files in This Item:
File Description SizeFormat
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

PubMed Central
Citations

1
checked on Nov 23, 2021

SCOPUSTM   
Citations

17
checked on Nov 30, 2021

WEB OF SCIENCETM
Citations

17
checked on Dec 1, 2021

Google ScholarTM

Check

Altmetric

Dimensions


Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.