English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/152309
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Mitochondrial dysfunction in human pathologies

AuthorsMonsalve, María ; Borniquel, Sara; Valle, Inmaculada; Lamas Peláez, Santiago
Issue Date2007
PublisherFrontiers in Bioscience Publications
CitationFrontiers in Bioscience 12: 1131-1153 (2007)
AbstractThe integrity of mitochondrial function is fundamental to cell life. The cell demands for mitochondria and their complex integration into cell biology, extends far beyond the provision of ATP. It follows that disturbances of mitochondrial function lead to disruption of cell function, expressed as disease or even death. Mitochondria are major producers of free radical species and also possibly of nitric oxide, and are, at the same time, major targets for oxidative damage. In this review we consider recent developments in our knowledge of how the mitochondrial production of reactive oxygen species (ROS) plays a critical role in several major human pathologies. We will also consider recent advances in our understanding of the molecular mechanisms involved in mitochondrial ROS detoxification.
Publisher version (URL)https://doi.org/10.2741/2132
Identifiersdoi: 10.2741/2132
issn: 1093-9946
e-issn: 1093-4715
Appears in Collections:(IIBM) Artículos
(CIB) Artículos
Files in This Item:
File Description SizeFormat 
dysfunctionhumanpatho.pdf444,58 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.