English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/152305
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Mutual dependence of Foxo3a and PGC-1α in the induction of oxidative stress genes

AuthorsOlmos, Yolanda ; Valle, Inmaculada; Borniquel, Sara; Tierrez, Albert; Soria, Estrella ; Lamas Peláez, Santiago ; Monsalve, María
Issue Date2009
PublisherAmerican Society for Biochemistry and Molecular Biology
CitationJournal of Biological Chemistry 284(21): 14476-14484 (2009)
AbstractOxidative stress is a hallmark of metabolism-related diseases and a risk factor for atherosclerosis. FoxO factors have been shown to play a key role in vascular endothelial development and homeostasis. Foxo3a can protect quiescent cells from oxidative stress through the regulation of detoxification genes such as sod2 and catalase. Here we show that Foxo3a is a direct transcriptional regulator of a group of oxidative stress protection genes in vascular endothelial cells. Importantly, Foxo3a activity requires the transcriptional co-activator PGC-1α, because it is severely curtailed in PGC-1α-deficient endothelial cells. Foxo3a and PGC-1α appear to interact directly, as shown by co-immunoprecipitation and in vitro interaction assays, and are recruited to the same promoter regions. The notion that Foxo3a and PGC-1α interact directly to regulate oxidative stress protection genes in the vascular endothelium is supported by the observation that PGC-1α transcriptional activity at the sod2 (manganese superoxide dismutase) promoter requires a functional FoxO site. We also demonstrate that Foxo3a is a direct transcriptional regulator of PGC-1α, suggesting that an auto-regulatory cycle regulates Foxo3a/PGC-1α control of the oxidative stress response.
Publisher version (URL)https://doi.org/10.1074/jbc.M807397200
Identifiersdoi: 10.1074/jbc.M807397200
issn: 0021-9258
e-issn: 1083-351X
Appears in Collections:(CIB) Artículos
(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
Foxo3a.pdf609,18 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.