Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/152295
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Mitochondrial dysfunction in cholestatic liver diseases |
Autor: | Sastre, Juan; Tormos, Ana M.; Monsalve, María CSIC ORCID | Palabras clave: | Mitochondrial function Review Oxidative stress Apoptosis Bile acids |
Fecha de publicación: | 2012 | Editor: | Frontiers in Bioscience Publications | Citación: | Frontiers in Bioscience (Elite edition) 4: 2233-2252 (2012) | Resumen: | Cholestatic liver diseases are characterized by blockade of bile flow from the liver to the intestine, and accumulation of hydrophobic bile acids in the liver and plasma. As a consequence an inflammatory response evolves associated with increased apoptosis, oxidative stress, and eventually fibrosis. Cholestasis is associated with profound metabolic changes, alterations in the mitochondrial function, decreased fatty acid oxidation, and increased glycolisis. Mitochondria play a central role in the development of this liver disease because they mediate death receptor signaling - triggered by inflammatory cytokines or bile acids - and contribute to oxidative damage, metabolic disorder, and onset of fibrosis. During the pathogenesis of biliary cirrhosis mitochondria's need for renewal is hampered by a blunted mitochondrial biogenesis. Lack of stimulation of mitochondrial renewal helps to explain mitochondrial impairment in long-term cholestasis. The marked depletion of mitochondrial DNA and occurrence of mitochondrial DNA deletions are probably relevant contributors to the progression of this severe disease. All these findings certainly support the consideration of long-term cholestasis as a secondary mitochondrial hepatopathy. | Descripción: | et al. | Versión del editor: | http://dx.doi.org/10.2741/539 | URI: | http://hdl.handle.net/10261/152295 | DOI: | 10.2741/539 | Identificadores: | doi: 10.2741/539 issn: 1945-0494 e-issn: 1945-0508 |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
cholestaticliver.pdf | 335,31 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
16
checked on 20-mar-2024
SCOPUSTM
Citations
54
checked on 21-mar-2024
Page view(s)
372
checked on 27-mar-2024
Download(s)
507
checked on 27-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.