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Título

Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis: a possible regulating role for steroid acyltransferases

AutorJaner, Gemma; Lavado Parra, Ramón; Thibaut, Rémi; Porte Visa, Cinta
Palabras claveEstradiol
Mytilus galloprovincialis
Estradiol acyltransferases
Androstenedione
P450-aromatase
Estradiol sulfation
Fecha de publicación3-ago-2005
EditorElsevier
CitaciónAquatic Toxicology 75(1): 32-42 (2005)
ResumenMussels (Mytilus galloaprovincialis) were exposed to different concentrations of estradiol (20, 200, and 2000 ng/L) in a semi-static regime (1-day dosing intervals) for up to 7 days in an attempt to see how mussels deal with exogenous estrogenic compounds. Whole tissue free-estradiol levels were only significantly elevated at the high exposure dose, whereas total-estradiol (free + esterified) sharply increased in a dose-dependent manner, from 2 ng/g in controls to 258 ng/g at the high exposure group. Neither free nor esterified testosterone levels showed significant differences between control and exposed organisms. The results suggest the existence of mechanisms that allow mussels to maintain their hormonal levels stable, with the exception of the high exposure dose, and the important role that fatty acid esterification, e.g. palmitoyl-CoA:estradiol acyltransferases, may play within those mechanisms. Additionally, the activity of 17β-hydroxysteroid dehydrogenase (17β-HSD), 5α-reductase, P450-aromatase, and estradiol-sulfotransferases were investigated in digestive gland microsomal and cytosolic fractions. All these activities were differently affected by estradiol exposure. Overall, the study contributes to the better knowledge of molluscan endocrinology, and defines new mechanisms of regulation of free steroid-levels in mussels.
Descripción11 pages, 5 figures.-- PMID: 16083976 [PubMed].-- Printed version published Oct 5, 2005.
Versión del editorhttp://dx.doi.org/10.1016/j.aquatox.2005.01.012
URIhttp://hdl.handle.net/10261/15224
DOI10.1016/j.aquatox.2005.01.012
ISSN0166-445X (Print)
1879-1514 (Online)
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