Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/15224
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis: a possible regulating role for steroid acyltransferases

AuthorsJaner, Gemma; Lavado Parra, Ramón; Thibaut, Rémi; Porte Visa, Cinta CSIC ORCID
KeywordsEstradiol
Mytilus galloprovincialis
Estradiol acyltransferases
Androstenedione
P450-aromatase
Estradiol sulfation
Issue Date3-Aug-2005
PublisherElsevier
CitationAquatic Toxicology 75(1): 32-42 (2005)
AbstractMussels (Mytilus galloaprovincialis) were exposed to different concentrations of estradiol (20, 200, and 2000 ng/L) in a semi-static regime (1-day dosing intervals) for up to 7 days in an attempt to see how mussels deal with exogenous estrogenic compounds. Whole tissue free-estradiol levels were only significantly elevated at the high exposure dose, whereas total-estradiol (free + esterified) sharply increased in a dose-dependent manner, from 2 ng/g in controls to 258 ng/g at the high exposure group. Neither free nor esterified testosterone levels showed significant differences between control and exposed organisms. The results suggest the existence of mechanisms that allow mussels to maintain their hormonal levels stable, with the exception of the high exposure dose, and the important role that fatty acid esterification, e.g. palmitoyl-CoA:estradiol acyltransferases, may play within those mechanisms. Additionally, the activity of 17β-hydroxysteroid dehydrogenase (17β-HSD), 5α-reductase, P450-aromatase, and estradiol-sulfotransferases were investigated in digestive gland microsomal and cytosolic fractions. All these activities were differently affected by estradiol exposure. Overall, the study contributes to the better knowledge of molluscan endocrinology, and defines new mechanisms of regulation of free steroid-levels in mussels.
Description11 pages, 5 figures.-- PMID: 16083976 [PubMed].-- Printed version published Oct 5, 2005.
Publisher version (URL)http://dx.doi.org/10.1016/j.aquatox.2005.01.012
URIhttp://hdl.handle.net/10261/15224
DOI10.1016/j.aquatox.2005.01.012
ISSN0166-445X
E-ISSN1879-1514
Appears in Collections:(IDAEA) Artículos

Show full item record
Review this work

SCOPUSTM   
Citations

74
checked on Jan 18, 2022

WEB OF SCIENCETM
Citations

74
checked on Jan 12, 2022

Page view(s)

366
checked on Jan 24, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.